| Author | Rocha, Sura Wanessa Santos | |
| Author | França, Maria Eduarda Rocha de | |
| Author | Rodrigues, Gabriel Barros | |
| Author | Barbosa, Karla Patrícia Sousa | |
| Author | Nunes, Ana Karolina Santana | |
| Author | Pastor, André Filipe | |
| Author | Oliveira, Anne Gabrielle Vasconcelos | |
| Author | Oliveira, Wilma Helena | |
| Author | Luna, Rayana Leal Almeida | |
| Author | Peixoto, Christina Alves | |
| Access date | 2017-11-16T13:20:48Z | |
| Available date | 2017-11-16T13:20:48Z | |
| Document date | 2014 | |
| Citation | ROCHA, S. W. S. et al. Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. Mediators of Inflammation, v. 2014, p. 696383, 2014. | pt_BR |
| ISSN | 1466-1861 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/23210 | |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| MeSH | Anti-Inflammatory Agents | pt_BR |
| MeSH | pharmacology | pt_BR |
| MeSH | Chemical and Drug Induced Liver Injury | pt_BR |
| MeSH | drug therapy | pt_BR |
| MeSH | Diethylcarbamazine | pt_BR |
| MeSH | pharmacology | pt_BR |
| MeSH | Carbon Tetrachloride | pt_BR |
| MeSH | toxicity | pt_BR |
| Subject in Portuguese | Anti-Inflamatórios | pt_BR |
| Subject in Portuguese | Doença Hepática Induzida por Substâncias e Drogas | pt_BR |
| Subject in Portuguese | Dietilcarbamazina | pt_BR |
| Subject in Portuguese | Animais | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Cirrose Hepática | pt_BR |
| Subject in Portuguese | Camundongos Endogâmicos C57BL | pt_BR |
| Subject in Portuguese | Óxido Nítrico | pt_BR |
| Subject in Portuguese | Óxido Nítrico Sintase Tipo II | pt_BR |
| Subject in Portuguese | RNA Mensageiro | pt_BR |
| Title | Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1155/2014/696383 | |
| Abstract | This study investigated the anti-inflammatory effects of DEC on the CCl4-induced hepatotoxicity in C57BL/6 mice. Chronic inflammation was induced by i.p. administration of CCl4 0.5 μL/g of body weight through two injections a week for 6 weeks. DEC (50 mg/kg) was administered by gavage for 12 days before finishing the CCl4 induction. Histological analyses of the DEC-treated group exhibited reduced inflammatory process and prevented liver necrosis and fibrosis. Immunohistochemical and immunofluorescence analyses of the DEC-treated group showed reduced COX-2, IL1β, MDA, TGF-β, and αSMA immunopositivity, besides exhibiting decreased IL1β, COX-2, NFκB, IFNγ, and TGFβ expressions in the western blot analysis. The DEC group enhanced significantly the IL-10 expression. The reduction of hepatic injury in the DEC-treated group was confirmed by the COX-2 and iNOS mRNA expression levels. Based on the results of the present study, DEC can be used as a potential anti-inflammatory drug for chronic hepatic inflammation. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Subject | Anti-Inflammatory Agents | pt_BR |
| Subject | Chemical and Drug Induced Liver Injury | pt_BR |
| Subject | Diethylcarbamazine | pt_BR |
| Subject | Animals | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | Liver Cirrhosis | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
