| Author | Delatorre, Edson | |
| Author | Fernandez, Jose Carlos Couto | |
| Author | Bello, Gonzalo | |
| Access date | 2017-11-16T14:29:14Z | |
| Available date | 2017-11-16T14:29:14Z | |
| Document date | 2017 | |
| Citation | DELATORRE, Edson; FERNANDEZ, Jose Carlos Couto; BELLO, Gonzallo. HIV-1 Genetic Diversity in Northeastern Brazil: High Prevalence of Non-B Subtypes. Aids Research and Human Retroviruses, v.33, n.7, p.639-647, 2017. | pt_BR |
| ISSN | 0889-222 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/23222 | |
| Language | eng | pt_BR |
| Publisher | Mary Ann Liebert | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | HIV | pt_BR |
| Subject in Portuguese | Região Nordeste | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Subject in Portuguese | Subtipos | pt_BR |
| Title | HIV-1 Genetic Diversity in Northeastern Brazil: High Prevalence of Non-B Subtypes | pt_BR |
| Type | Article | |
| DOI | 10.1089/AID.2017.0045 | |
| Abstract | The Northeastern Brazilian region has experienced a constant increase in the number of newly reported AIDS cases over the last decade, but the genetic diversity of HIV-1 strains currently disseminated in this region remains poorly explored. HIV-1 pol sequences were obtained from 140 patients followed at outpatient clinics from four Northeastern Brazilian states (Alagoas, Bahia, Ceará, and Piauí) between 2014 and 2015. Subtype B was the most prevalent HIV-1 clade (72%) detected in the Northeastern region, followed by subtypes F1 (6%), C (5%), and D (1%). The remaining strains (16%) displayed a recombinant structure and were classified as follows: BF1 (11%), BC (4%), BCF1 (1%), and CRF02_AG like (1%). The 20 HIV-1 BF1 and BC recombinant sequences detected were distributed among 11 lineages classified as follows: CRF28/29_BF like (n = 5), CRF39_BF like (n = 1), URF_BF (n = 9), and URF_BC (n = 5). Non-B subtypes were detected in all Northeastern Brazilian states, but with variable prevalence, ranging from 16% in Ceará to 55% in Alagoas. Phylogenetic analyses support that subtype D and CRF02_AG strains detected in the Northeastern region resulted from the expansion of autochthonous transmission networks, rather than from exogenous introductions from other countries. These results reveal that HIV-1 epidemic spreading in the Northeastern Brazilian region comprised by multiple subtypes and recombinant strains and the molecular epidemiologic pattern in this Brazilian region is much more complex than originally estimated. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | HIV | pt_BR |
| Subject | subtypes | pt_BR |
| Subject | Northeastern region | pt_BR |
| Subject | Brazil | pt_BR |
| e-ISSN | 1931-8405 | |
| Embargo date | 2030-01-01 | |
