| Author | Martins, Albert Eduardo Silva | |
| Author | Lucena-Silva, Norma | |
| Author | Garcia, Renan Gomes | |
| Author | Welkovic, Stefan | |
| Author | Barboza, Aureliana | |
| Author | Menezes, Maria Luiza Bezerra | |
| Author | Maruza, Magda | |
| Author | Tenório, Terezinha | |
| Author | Ximenes, Ricardo A. A. | |
| Access date | 2017-11-20T11:50:55Z | |
| Available date | 2017-11-20T11:50:55Z | |
| Document date | 2014 | |
| Citation | MARTINS, A. E. S. et al. Prevalence of human papillomavirus infection, distribution of viral types and risk factors in cervical samples from human immunodeficiency virus-positive women attending three human immunodeficiency virus-acquired immune deficiency syndrome reference centres in northeastern Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 6, p. 738–747, set. 2014. | pt_BR |
| ISSN | 1678-8060 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/23265 | |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Fatores de Risco | pt_BR |
| Subject in Portuguese | prevalência de HPV | pt_BR |
| Subject in Portuguese | Co-infecção por HIV-HPV | pt_BR |
| Subject in Portuguese | Tipos de HPV | pt_BR |
| Title | Prevalence of human papillomavirus infection, distribution of viral types and risk factors in cervical samples from human immunodeficiency virus-positive women attending three human immunodeficiency virus-acquired immune deficiency syndrome reference centres in northeastern Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/0074-0276140070 | |
| Abstract | Human immunodeficiency virus (HIV)-positive patients have a greater prevalence of coinfection with human papillomavirus (HPV) is of high oncogenic risk. Indeed, the presence of the virus favours intraepithelial squamous cell lesion progression and may induce cancer. The aim of this study was to evaluate the prevalence of HPV infection, distribution of HPV types and risk factors among HIV-positive patients. Cervical samples from 450 HIV-positive patients were analysed with regard to oncotic cytology, colposcopy and HPV presence and type by means of polymerase chain reaction and sequencing. The results were analysed by comparing demographic data and data relating to HPV and HIV infection. The prevalence of HPV was 47.5%. Among the HPV-positive samples, 59% included viral types of high oncogenic risk. Multivariate analysis showed an association between HPV infection and the presence of cytological alterations (p = 0.003), age greater than or equal to 35 years (p = 0.002), number of partners greater than three (p = 0.002), CD4⁺ lymphocyte count < 200/mm³ (p = 0.041) and alcohol abuse (p = 0.004). Although high-risk HPV was present in the majority of the lesions studied, the low frequency of HPV 16 (3.3%), low occurrence of cervical lesions and preserved immunological state in most of the HIV-positive patients were factors that may explain the low occurrence of precancerous cervical lesions in this population. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunogenética. Recife, PE, Brasil / Instituto de Medicina Integral Professor Fernando Figueira. Hospital de Ensino. Departamento de Oncologia Pediátrica. Laboratório de Biologia Molecular. Recife, PE, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunogenética. Recife, PE, Brasil / Instituto de Medicina Integral Professor Fernando Figueira. Hospital de Ensino. Departamento de Oncologia Pediátrica. Laboratório de Biologia Molecular. Recife, PE, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunogenética. Recife, PE, Brasil. | |
| Affilliation | Centro Integrado de Saúde Amaury de Medeiros. Disciplina de Obstetrícia e Ginecologia. Recife, PE, Brasil. | |
| Affilliation | Universidade de Pernambuco. Faculdade de Ciências Médicas. Departamento Materno-Infantil. Recife, PE, Brasil. | |
| Affilliation | Universidade de Pernambuco. Faculdade de Ciências Médicas. Departamento Materno-Infantil. Recife, PE, Brasil. | |
| Affilliation | Secretaria de Saúde de Pernambuco. Hospital Correia Picanço. Recife, PE, Brasil. | |
| Affilliation | Universidade Federal de Pernambuco. Departamento Materno-Infantil. Recife, PE, Brasil. | |
| Affilliation | Universidade Federal de Pernambuco. Departamento de Medicina Tropical. Recife, PE, Brasil. | |
| Subject | HPV prevalence | pt_BR |
| Subject | HPV typing distribution | pt_BR |
| Subject | HIV-HPV coinfection | pt_BR |
| Subject | risk factors | pt_BR |
| Subject | HPV types | pt_BR |
| DeCS | Síndrome de Imunodeficiência Adquirida | pt_BR |
| DeCS | virologia | pt_BR |
| DeCS | Colo do Útero | pt_BR |
| DeCS | virologia | pt_BR |
| DeCS | Soroprevalência de HIV | pt_BR |
| DeCS | Consumo de Bebidas Alcoólicas | pt_BR |
| DeCS | Papillomaviridae | pt_BR |
| DeCS | classificação | pt_BR |
| DeCS | Infecções por Papillomavirus | pt_BR |
| DeCS | epidemiologia | pt_BR |
| DeCS | HIV | pt_BR |
| DeCS | imunologia | pt_BR |
| DeCS | Inquéritos e Questionários | pt_BR |
| DeCS | Centros de Atenção Terciária | pt_BR |
| DeCS | Contagem de Linfócito CD4 | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Renda | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Brasil | pt_BR |
| DeCS | epidemiologia | pt_BR |
