Author | Santos, Patrícia d'Emery Alves | |
Author | Lorena, Virgínia Maria Barros | |
Author | Fernandes, Érica | |
Author | Sales, Iana Rafaela Fernandes | |
Author | Albuquerque, Mônica Camelo Pessoa | |
Author | Gomes, Yara | |
Author | Costa, Vlaudia Maria Assis | |
Author | Souza, Valdênia Maria Oliveira | |
Access date | 2017-11-27T14:31:44Z | |
Available date | 2017-11-27T14:31:44Z | |
Document date | 2014 | |
Citation | SANTOS, P. D’EMERY A. et al. Maternal schistosomiasis alters costimulatory molecules expression in antigen-presenting cells from adult offspring mice. Experimental Parasitology, v. 141, p. 62–67, jun. 2014. | pt_BR |
ISSN | 1090-2449 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/23368 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Crianças Adultas | pt_BR |
Subject in Portuguese | Aleitamento Materno | pt_BR |
Subject in Portuguese | Moléculas estimuladoras | pt_BR |
Subject in Portuguese | Gravidez | pt_BR |
Subject in Portuguese | Esquistossomose materna | pt_BR |
Title | Maternal schistosomiasis alters costimulatory molecules expression in antigen-presenting cells from adult offspring mice | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.exppara.2014.03.017 | |
Abstract | Adult offspring of Schistosoma mansoni-infected mice showed alterations in immunity to a heterologous antigen, ovalbumin (OA). Prior breastfeeding induced increased production of anti-OA antibodies, while pregnancy impaired it. Here, we investigated the expression of costimulatory molecules on antigen-presenting cells (APCs) of the adult offspring of S. mansoni-infected mothers in response to OA. Newborn mice were divided into three groups: animals Born Infected Mothers (BIM) suckled by non-infected mothers; animals from non-infected mothers Suckled Infected Mothers (SIM); and another group of mice born from and suckled by non-infected mothers (CONTROL). The adult offspring were immunized with subcutaneous OA+adjuvant, and 3-8days following immunization, double labeling was performed (CD45R/B220 or CD11c and CD80, CD86, CD40 or HLA-DR) on spleen cells. In comparison to the CONTROL group, an early increased frequency of CD40+/CD80+ B cells was observed in SIM mice (p<0.001/p<0.05), but no alteration of CD11c+ cells was observed. In contrast, in BIM mice, the frequency of CD86+/CD11c+ cells (p<0.05) and CD40+/CD80+/CD86+ B cells (p<0.01/p<0.01/p<0.05) was drastically reduced. In conclusion, previous suckling by S. mansoni-infected mothers enabled improved antigen presentation by B cells in adult offspring, whereas gestation in these mothers imprinted offspring with weak antigen presentation by APCs during the immune response to a non-related antigen. | pt_BR |
Affilliation | Federal University of Pernambuco. Laboratory of Immunology, Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
Affilliation | Federal University of Pernambuco. Laboratory of Immunology, Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil. | pt_BR |
Affilliation | Federal University of Pernambuco. Laboratory of Immunology, Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil. | pt_BR |
Affilliation | Federal University of Pernambuco. Laboratory of Immunology, Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil / Federal University of Pernambuco. Health Sciences Center. Department of Tropical Medicine. Recife, PE, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
Affilliation | Federal University of Pernambuco. Laboratory of Immunology, Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil / Federal University of Pernambuco. Health Sciences Center. Department of Tropical Medicine. Recife, PE, Brazil. | pt_BR |
Affilliation | Federal University of Pernambuco. Laboratory of Immunology, Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil / Federal University of Pernambuco. Health Sciences Center. Department of Pharmaceutical Sciences. Recife, PE, Brazil. | pt_BR |
Subject | Adult offspring | pt_BR |
Subject | Breastfeeding | pt_BR |
Subject | Costimulatory molecules | pt_BR |
Subject | Gestation | pt_BR |
Subject | Maternal schistosomiasis | pt_BR |
DeCS | Células Apresentadoras de Antígenos | pt_BR |
DeCS | imunologia | pt_BR |
DeCS | Antígenos CD | pt_BR |
DeCS | metabolismo | pt_BR |
DeCS | Imunidade Materno-Adquirida | pt_BR |
DeCS | Complicações Parasitárias na Gravidez | pt_BR |
DeCS | Esquistossomose mansoni | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Antígenos CD40 | pt_BR |
DeCS | Antígenos CD80 | pt_BR |
DeCS | Antígenos CD86 | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Transmissão Vertical de Doença Infecciosa | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Gravidez | pt_BR |
DeCS | Esquistossomose mansoni | pt_BR |
DeCS | transmissão | pt_BR |