| Author | Oliveira, Luiz Filipe Gonçalves | |
| Author | Silva, Franklin Souza | |
| Author | Finkelstein, Léa Cysne | |
| Author | Rabelo, Kíssila | |
| Author | Amorim, Juliana Fernandes | |
| Author | Azevedo, Adriana de Souza | |
| Author | Bourguignon, Saulo Cabral | |
| Author | Ferreira, Vitor Francisco | |
| Author | Paes, Marciano Viana | |
| Author | Alves, Carlos Roberto | |
| Access date | 2017-11-30T15:19:55Z | |
| Available date | 2017-11-30T15:19:55Z | |
| Document date | 2017 | |
| Citation | OLIVEIRA, Luiz Filipe Gonçalves de; et al. Evidence for Tissue Toxicity in BALB/c Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate. BioMed Research International, Volume 2017, Article ID 984210, 11p, 2017. | pt_BR |
| ISSN | 2314-6133 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/23474 | |
| Language | eng | pt_BR |
| Publisher | Hindawi Publishing Corporation | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Leishmaniose | pt_BR |
| Subject in Portuguese | Tratamento | pt_BR |
| Subject in Portuguese | Antimoniato de Meglumina | pt_BR |
| Subject in Portuguese | Camundongos Endogâmicos BALB C | pt_BR |
| Title | Evidence for Tissue Toxicity in BALB/c Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1155/2017/9840210 | |
| Abstract | Leishmaniasis remains a serious public health problem in developing countries without effective control, whether by vaccination or chemotherapy. Part of the failure of leishmaniasis control is due to the lack of new less toxic and more effective drugs able to eliminate both the lesions and the parasite. Oxiranes derived from naphthoquinones now being assayed are promising drugs for the treatment of this group of diseases. The predicted pharmacokinetic properties and toxicological profiles of epoxy-α-lapachone and epoxymethoxy-lawsone have now been compared to those of meglumine antimoniate, and histological changes induced by these drugs in noninfected BALB/c mice tissues are described. Effects of these compounds on liver, kidney, lung, heart, and cerebral tissues of healthy mice were examined. The data presented show that both these oxiranes and meglumine antimoniate induce changes in all BALB/c mice tissues, with the lung, heart, and brain being the most affected. Epoxymethoxy-lawsone was the most toxic to lung tissue, while most severe damage was caused in the heart by epoxy-α-lapachone. Meglumine antimoniate caused mild-to-moderate changes in heart and lung tissues. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia Virológica,.Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia Virológica,.Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Leishmaniasis | pt_BR |
| Subject | Treatment | pt_BR |
| Subject | Meglumine antimoniate | pt_BR |
| Subject | BALB/c mice | pt_BR |
| e-ISSN | 2314-6141 | |
