| Author | Almeida, Francine Maria | |
| Author | Romanholo, Beatriz Mangueira Saraiva | |
| Author | Vieira, Rodolfo Paula | |
| Author | Moriya, Henrique Takachi | |
| Author | Oliveira, Ana Paula Ligeiro de | |
| Author | Lopes, Fernanda Dtqs | |
| Author | Faria Neto, Hugo C. | |
| Author | Mauad, Thais | |
| Author | Martins, Milton Arruda | |
| Author | Pazetti, Rogerio | |
| Access date | 2017-12-07T13:54:20Z | |
| Available date | 2017-12-07T13:54:20Z | |
| Document date | 2017 | |
| Citation | ALMEIDA, Francine Maria; et al. Compensatory lung growth after bilobectomy in emphysematous rats. Plos One, v.12, n.7, e0181819, 14p, July 2017. | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/23541 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Cirurgia de redução do volume pulmonar | pt_BR |
| Subject in Portuguese | pacientes enfisematosos | pt_BR |
| Subject in Portuguese | Bilobectomia | pt_BR |
| Title | Compensatory lung growth after bilobectomy in emphysematous rats | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0181819 | |
| Abstract | Lung volume reduction surgery (LVRS) is an option for emphysematous patients who are awaiting lung transplantation. LVRS reduces nonfunctional portions of lung tissues and favors the compensatory lung growth (CLG) of the remaining lobes. This phenomenon diminishes dyspnea and improves both the respiratory mechanics and quality of life for the patients. An animal model of elastase-induced pulmonary emphysema was used to investigate the structural and functional lung response after LVRS. Bilobectomy was performed six weeks after elastase instillation. Two weeks after bilobectomy, CLG effects were evaluated by lung mechanics and histomorphometric analysis. After bilobectomy, the emphysematous animals presented decreased mean linear intercepts, increased elastic fiber proportion, and increased alveolar surface density, total volumes of airspace, tissue and respiratory region and absolute surface area. We conclude that bilobectomy promoted CLG in emphysematous animals, resulting in alveolar architecture repair. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil /Instituto de Assistência Médica ao Servidor Público Estadual. Universidade Cidade de São Paulo. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Brasil Escola de Ciências Médicas de São José dos Campos Humanitas. Instituto Brasileiro de Ensino e Pesquisa em Imunologia Pulmonar e de Exercício. São Paulo, Brasil | pt_BR |
| Affilliation | Universidade de São Paulo. Laboratório de Engenharia Biomédica. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Universidade Brasil Escola de Ciências Médicas de São José dos Campos Humanitas. Instituto Brasileiro de Ensino e Pesquisa em Imunologia Pulmonar e de Exercício. São Paulo, Brasil | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Cardiopneumologia. São Paulo, SP, brasil | pt_BR |
| Subject | Lung volume reduction surgery | pt_BR |
| Subject | emphysematous patients | pt_BR |
| Subject | bilobectomy | pt_BR |
