| Author | Castro, Murilo Fagundes | |
| Author | Meira, Cássio Santana | |
| Author | Bastos, Tanira Matutino | |
| Author | Guimarães, Elisalva Teixeira | |
| Author | Macambira, Simone Garcia | |
| Author | Soares, Milena Botelho Pereira | |
| Access date | 2017-12-07T19:26:57Z | |
| Available date | 2017-12-07T19:26:57Z | |
| Document date | 2012 | |
| Citation | CASTRO, M. F. et al. In vitro and in vivo evaluation of anti-Trypanosoma cruzi activity of derivates of vitamin K. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/23560 | |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Medicina Tropical | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Quimioterapia | pt_BR |
| Subject in Portuguese | Vitamina K | pt_BR |
| Subject in Portuguese | Microscopia eletrônica | pt_BR |
| Subject in Portuguese | Humanos | pt_BR |
| Title | In vitro and in vivo evaluation of anti-Trypanosoma cruzi activity of derivates of vitamin K | pt_BR |
| Type | Papers presented at events | pt_BR |
| Abstract | About 10 million people worldwide are infected by Trypanosoma cruzi, etiologic agent of Chagas disease.
The absence of effective trypanocidal chemotherapy reflects the need for constant research in this area.
Some compounds such as naphtoquinones can reduce trypanothione reductase (TR), specific enzyme of
trypanossomatids, which controls cellular oxidative stress. Inhibition of TR favors an oxidative process and
death of the parasite. In this work, we investigate the trypanocidal potential of phytomenadione (K1) and
menadione (K3), both vitamins K derived from naphthoquinones. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Federal University of Bahia. Department of Biophysics. Salvador, BA, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | Chemotherapy | pt_BR |
| Subject | Vitamin K | pt_BR |
| Subject | Electron microscopy | pt_BR |
| Subject | Humans | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
