| Author | Oliveira, S. V. de | |
| Author | Willemann, M. C. A. | |
| Author | Gazeta, G. S. | |
| Author | Angerami, R. N. | |
| Author | Gonçalves, R. Gurgel | |
| Access date | 2017-12-11T12:38:54Z | |
| Available date | 2017-12-11T12:38:54Z | |
| Document date | 2017 | |
| Citation | OLIVEIRA, S. V. de; et al. Predictive Factors for Fatal Tick-Borne Spotted Fever in Brazil. Zoonoses and Public Health, v.64, e44-e50, 201'7. | pt_BR |
| ISSN | 1863-1959 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/23593 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Febre manchada | pt_BR |
| Subject in Portuguese | Fatores preditivos | pt_BR |
| Subject in Portuguese | Carrapatos | pt_BR |
| Subject in Portuguese | Rickettsia rickettsii | pt_BR |
| Title | Predictive Factors for Fatal Tick-Borne Spotted Fever in Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1111/zph.12345 | |
| Abstract | In Brazil, two pathogenic Rickettsia species have been identified causing tick-borne spotted fever (SF). The aetiological agent Rickettsia rickettsii causes serious illness, particularly in the south-eastern region of the country. Moreover, the Rickettsia sp. strain Atlantic Rainforest cause milder clinical manifestations in south-eastern, south and north-east regions. This study has sought to analyse predictive factors for fatal SF. A case-control study was performed using disease notification records in Brazil. The cases included were individuals with laboratory confirmation and fatal progression of SF, while the controls included individuals with SF who were cured. A total of 386 cases and 415 controls were identified (1 : 1.1), and the cases and controls were similar in age. The factors identified as being protective against death were reported presence of ticks (odds ratio [OR], 0.60; 95% confidence interval [CI], 0.41-0.88), residing in urban areas (OR, 0.47, 95% CI, 0.31-0.74) and presenting lymphadenopathy (OR, 0.43; 95% CI, 0.23-0.82). Males exhibited a greater chance of death (OR, 1.57; 95% CI, 1.13-2.18), as did patients who were hospitalized (OR, 10.82; 95% CI, 6.38-18.35) and who presented hypotension or shock (OR, 10.80; 95% CI, 7.33-15.93), seizures (OR, 11.24; 95% CI, 6.49-19.45) and coma (OR of 15.16; 95% CI, 8.51-27.02). The study demonstrates the severity profile of the SF cases, defined either as the frequency of hospitalization (even in cases that were cured) or as the increased frequency of the clinical complications typically found in critical patients. Opportune clinical diagnosis, a careful evaluation of the epidemiological aspects of the disease and adequate care for patients are determining factors for reducing SF fatality rates. | pt_BR |
| Affilliation | Universidade de Brasília. Programa de Pós Graduação em Medicina Tropical. Brasília, DF, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Secretaria Estadual de Saúde de Santa Catarina. Departamento de Vigilância em Saúde. Florianópolis, SC, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Estadual de Campinas. Hospital de Clínicas. Campinas, SP, Brasil. | pt_BR |
| Affilliation | Universidade de Brasília. Laboratório de Parasitologia Médica e Biologia de Vetores. Brasília, DF, Brasil. | pt_BR |
| Subject | Spotted fever | pt_BR |
| Subject | Predictive Factors | pt_BR |
| Subject | Fatal Tick-Borne | pt_BR |
| Subject | Rickettsia species | pt_BR |
| e-ISSN | 1863-2378 | |
| Embargo date | 2030-01-01 | |
