| Author | Ferreira, Clarissa de Castro | |
| Author | Azevedo, Ana Carolina Campi | |
| Author | Pascoal, Vanessa Peruhype Magalhāes | |
| Author | Pereira, Christiane Costa | |
| Author | Albuquerque, Cleandro Pires de | |
| Author | Muniz, Luciana Feitosa | |
| Author | Souza, Talita Yokoy de | |
| Author | Oliveira, Ana Cristina Vanderley | |
| Author | Martins Filho, Olindo Assis | |
| Author | Mota, Licia Maria Henrique da | |
| Access date | 2017-12-11T17:17:40Z | |
| Available date | 2017-12-11T17:17:40Z | |
| Document date | 2017 | |
| Citation | FERREIRA, Clarissa de Castro et al. The 17d-204 and 17dd yellow fever vaccines: an overview of major similaries and subtle differences. Expert Review of Vaccines, 2017 | pt_BR |
| ISSN | 1476-0584 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/23606 | |
| Language | eng | pt_BR |
| Publisher | Taylor & Francis | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | adaptação de imunorespostas | pt_BR |
| Subject in Portuguese | reações adversas | pt_BR |
| Subject in Portuguese | febre amarela | pt_BR |
| Subject in Portuguese | imuno resposta inata | pt_BR |
| Title | The 17D-204 and 17DD yellow fever vaccines: an overview of major similarities and subtle differences | pt_BR |
| Type | Article | |
| DOI | 10.1080/14760584.2018.1406800 | |
| Abstract | Introduction: The yellow fever vaccine is a live attenuated virus vaccine that is considered one of the most efficient vaccines produced to date. The original 17D strain generated the substrains 17D-204 and 17DD, which are used for the current production of vaccines against yellow fever. The 17D-204 and 17DD substrains present subtle differences in their nucleotide compositions, which can potentially lead to variations in immunogenicity and reactogenicity. We will address the main changes in the immune responses induced by the 17D-204 and 17DD yellow fever vaccines and report similarities and differences between these vaccines in cellular and humoral immunity . This is a relevant issue in view of the re-emergence of yellow fever in Uganda in 2016 and in Brazil in the beginning of 2017.
Areas covered: This article will be divided into 8 sections that will analyze the innate immune response, adaptive immune response, humoral response, production of cytokines, immunity in children, immunity in the elderly, gene expression and adverse reactions.
Expert commentary: The 17D-204 and 17DD yellow fever vaccines present similar immunogenicity, with strong activation of the cellular and humoral immune responses. Additionally, both vaccines have similar adverse effects, which are mostly mild and thus are considered safe. | pt_BR |
| Affilliation | Universidade de Brasilia. Hospital Universitário de Brasilia. Departamento de Reumatologia. Brasilia, DF, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade de Brasilia. Hospital Universitário de Brasilia. Departamento de Reumatologia. Brasilia, DF, Brazil | pt_BR |
| Affilliation | Universidade de Brasilia. Hospital Universitário de Brasilia. Departamento de Reumatologia. Brasilia, DF, Brazil | pt_BR |
| Affilliation | Universidade de Brasilia. Hospital Universitário de Brasilia. Departamento de Reumatologia. Brasilia, DF, Brazil | pt_BR |
| Affilliation | Universidade de Brasilia. Hospital Universitário de Brasilia. Departamento de Reumatologia. Brasilia, DF, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade de Brasilia. Hospital Universitário de Brasilia. Departamento de Reumatologia. Brasilia, DF, Brazil | pt_BR |
| Subject | Adaptive immune response | pt_BR |
| Subject | adverse reactions | pt_BR |
| Subject | innate immune response | pt_BR |
| Subject | yellow fever | pt_BR |
| Subject | yellow fever vaccine | pt_BR |
| Subject | cytokines | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
