| Author | Chimelli, Leila | |
| Author | Portari, Elyzabeth Avvad | |
| Access date | 2017-12-12T12:50:44Z | |
| Available date | 2017-12-12T12:50:44Z | |
| Document date | 2017 | |
| Citation | CHIMELLI, Leila; PORTARI, Elyzabeth Avvad. Congenital Zika virus infection: a neuropathological review. Child's Nervous System, p. 1-5, Nov. 2017. | pt_BR |
| ISSN | 1433-0350 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/23618 | |
| Language | eng | pt_BR |
| Publisher | Springer Verlag | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Infecção Congênita por Virus Zika | pt_BR |
| Subject in Portuguese | Neuropatologia | pt_BR |
| Subject in Portuguese | Microcefalia | pt_BR |
| Subject in Portuguese | Ventriculomegalia | pt_BR |
| Subject in Portuguese | Calcificação | pt_BR |
| Title | Congenital Zika virus infection: a neuropathological review | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1007/s00381-017-3651-3 | |
| Abstract | Background A relationship between Zika virus (ZikV) infection in pregnancy and the occurrence of microcephaly wasestablished during the Zika outbreak in Brazil (2015– 2016).
Neuropathological findings in congenital Zika syndromem helped to understand its pathogenetic mechanisms.
Results The most relevant postmortem findings in the central
nervous system (CNS) of fetuses and neonates infected with
ZikV early in gestation are microcephaly with ex-vacuo
ventriculomegaly and large head circumference associated with
obstructive hydrocephalus due to severe midbrain and aqueduct
distortion. Babies with severe brain lesions are born with
arthrogryposis. Histologically, there is extensive destruction of
the hemispheric parenchyma, calcifications, various distur-
bances of neuronal migration, reactive gliosis, microglial hyper-
plasia and occasional perivascular cuffs of lymphocytes, also in
the meninges. Hypoplastic lesions secondary to the lack of de-
scending nerve fibers include small basis pontis, pyramids and
spinal corticospinal tracts. Cerebellar hypoplasia is also com-
mon. Severe nerve motor nerve cell loss is observed in the
anterior horn of the spinal cord.
Conclusion A spectrum of neuropathological changes, from
severe microcephaly to obstructive hydrocephalus was ob-
served. The severity of the lesions is directly related to the
gestational age, the most severe occurring when the mother
is infected in the first trimester. Infection of progenitor cells at | pt_BR |
| Affilliation | State Institute of Brain Paulo Niemeyer and Federal University of Rio de Janeiro. Laboratory of Neuropathology. Rio de Janeiro, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Congenital Zika virus infection | pt_BR |
| Subject | Neuropathology | pt_BR |
| Subject | Microcephaly | pt_BR |
| Subject | Ventriculomegaly | pt_BR |
| Subject | Calcification | pt_BR |
| Embargo date | 2018-12-31 | |
