| Author | Wajnberg, Gabriel | |
| Author | Passetti, Fabio | |
| Access date | 2017-12-30T13:11:40Z | |
| Available date | 2017-12-30T13:11:40Z | |
| Document date | 2016 | |
| Citation | WAJNBERG, Gabriel; PASSETTI, Fabio. Using high-throughput sequencing transcriptome data for INDEL detection: challenges for cancer drug discovery. Expert Opinion on Drug Discovery, v.11, n.3, p.257-268, 2016. | pt_BR |
| ISSN | 1746-0441 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/23832 | |
| Language | eng | pt_BR |
| Publisher | Taylor & Francis | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Câncer | pt_BR |
| Subject in Portuguese | Medicamentos | pt_BR |
| Subject in Portuguese | Mutação INDEL | pt_BR |
| Subject in Portuguese | Sequência de Bases | pt_BR |
| Title | Using high-throughput sequencing transcriptome data for INDEL detection: challenges for cancer drug discovery | pt_BR |
| Type | Article | |
| DOI | 10.1517/17460441.2016.1143813 | |
| Abstract | A cancer cell is a mosaic of genomic and epigenomic alterations. Distinct cancer molecular signatures can be observed depending on tumor type or patient genetic background. One type of genomic alteration is the insertion and/or deletion (INDEL) of nucleotides in the DNA sequence, which may vary in length, and may change the encoded protein or modify protein domains. INDELs are associated to a large number of diseases and their detection is done based on low-throughput techniques. However, high-throughput sequencing has also started to be used for detection of novel disease-causing INDELs. This search may identify novel drug targets. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Cancer | pt_BR |
| Subject | Drug discovery | pt_BR |
| Subject | INDEL | pt_BR |
| Subject | DNA sequence | pt_BR |
| e-ISSN | 1746-045X | |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
