| Author | Rabelo, Kissila | |
| Author | Fernandes, Regina Célia de Souza Campos | |
| Author | Souza, Luiz José | |
| Author | Souza, Thais Louvain de | |
| Author | Santos, Flávia Barreto dos | |
| Author | Nunes, Priscila Conrado Guerra | |
| Author | Azeredo, Elzinandes Leal de | |
| Author | Salomão, Natália Gedeão | |
| Author | Trindade, Gisela Freitas | |
| Author | Oliveira, Carlos A. Basílio de | |
| Author | Carvalho, Jorge José de | |
| Author | Medina-Acosta, Enrique | |
| Author | Paes, Marciano Viana | |
| Access date | 2018-01-16T13:59:35Z | |
| Available date | 2018-01-16T13:59:35Z | |
| Document date | 2017 | |
| Citation | RABELO, Kissila; et al. Placental Histopathology and Clinical Presentation of Severe Congenital Zika Syndrome in a Human Immunodeficiency Virus-Exposed Uninfected Infant. Frontiers in Immunology, v.8:1704, 8p, Dec. 2017. | pt_BR |
| ISSN | 1664-3224 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/23924 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Zika virus | pt_BR |
| Subject in Portuguese | Placenta | pt_BR |
| Subject in Portuguese | Histopatologia | pt_BR |
| Subject in Portuguese | Microcefalia | pt_BR |
| Subject in Portuguese | Síndrome congénita de Zika | pt_BR |
| Subject in Portuguese | vírus da imunodeficiência humana | pt_BR |
| Subject in Portuguese | Crianças | pt_BR |
| Title | Placental histopatology and clinical presentation of severe congenital Zika Syndrome in a human immunodeficiency virus-exposed uninfected infant | pt_BR |
| Type | Article | |
| DOI | 10.3389/fimmu.2017.01704 | |
| Abstract | In the large Zika virus (ZIKV) epidemic that occurred in Brazil in 2015, the intrauterine
fetal exposure to ZIKV was associated with a significant risk of developing microcephaly
and neurological disorders in the infected infants. ZIKV-associated disease has since
been reported in 24 countries in the Americas. At present, definitive evidence is lacking
regarding the intrauterine co-exposure to ZIKV and other viral infections and whether
the coinfection impacts the risk of acquiring either infection or disease severity. Here,
we provide evidence of intrauterine exposure to both ZIKV and human immunodeficiency
virus (HIV) infections, causing congenital Zika syndrome in an HIV-exposed
uninfected infant. Clinical, imaging and laboratory examinations of the pregnant woman
and the newborn were performed. Histopathology, ZIKV/HIV-specific immunoassays,
and ultrastructural evaluation of the placenta were performed. The Zika-asymptomatic,
HIV-positive pregnant woman underwent ultrasounds revealing fetal cerebral ventriculomegaly,
microcephaly, and brain atrophy. Her baby girl was born small for gestational
age and with the neurological sequelae of congenital Zika syndrome. The evaluation of
the abnormally large term placenta revealed severe damage to the maternal decidua
and chorionic villi, cells positive for ZIKV-specific antigens but not for HIV antigens,
and intracellular membranous clusters of virus-like particles approximately 25 nm in
diameter. The rapid progression and severity of the congenital Zika syndrome may be
related to the uncontrolled HIV disease in the mother. The poor inflammatory response
observed in the placenta may have reduced the inherent risk of mother-to-child transmission
of HIV. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brasil / Universidade Estadual do Norte Fluminense. Laboratório de Biotecnologia. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
| Affilliation | Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
| Affilliation | Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brasil / Universidade Estadual do Norte Fluminense. Laboratório de Biotecnologia. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Biomanguinhos. Laboratório de Tecnologia Virológica. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Anatomia Patológica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Norte Fluminense. Laboratório de Biotecnologia. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Zika virus | pt_BR |
| Subject | placenta | pt_BR |
| Subject | congenital Zika syndrome | pt_BR |
| Subject | histopathology | pt_BR |
| Subject | microcephaly | pt_BR |
| Subject | human immunodeficiency virus | pt_BR |
| Subject | infant | pt_BR |
