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AutorCarvalho, Fernanda Marques de
AutorRodrigues, Luciana Silva
AutorDuppre, Nádia Cristina
AutorAlvim, Iris Maria Peixoto
AutorAlves, Marcelo Ribeiro
AutorPinheiro, Roberta Olmo
AutorSarno, Euzenir Nunes
AutorPessolani, Maria Cristina Vidal
AutorPereira, Geraldo Moura Batista
Fecha de acceso2018-02-20T13:09:20Z
Fecha de disponibilización2018-02-20T13:09:20Z
Fecha de publicación2017
ReferenciaCARVALHO, Fernanda Marques de et al. Interruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigens. PLoS Neglected Tropical Diseases, v. 11, n. 5, p. 1-16, May 2017.pt_BR
ISSN1935-2727pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/24878
Idiomaengpt_BR
EditorPublic Library of Sciencept_BR
Derechos de autoropen access
Palabras clave en PortuguésHanseníasept_BR
Palabras clave en PortuguésMycobacterium lepraept_BR
Palabras clave en PortuguésVacina BCGpt_BR
Palabras clave en PortuguésAntígenospt_BR
TítuloInterruption of persistent exposure to leprosy combined or not with recent BCG vaccination enhances the response to Mycobacterium leprae specific antigenspt_BR
Tipo del documentoArticle
DOI10.1371/journal.pntd.0005560
Resumen en InglésHousehold contacts of multibacillary leprosy patients (HCMB) constitute the group of individuals at the highest risk of developing leprosy. Early diagnosis and treatment of their index cases combined with Bacille Calmette-Guerin (BCG) immunization remain important strategies adopted in Brazil to prevent HCMB from evolving into active disease. In the present study, we assessed the impact of these measures on the immune response to Mycobacterium leprae in HCMB. Peripheral blood mononuclear cells (PBMC) from HCMB (n = 16) were obtained at the beginning of leprosy index case treatment (T0). At this time point, contacts were vaccinated (n = 13) or not (n = 3) in accordance with their infancy history of BCG vaccination and PBMCs were recollected at least 6 months later (T1). As expected, a significant increase in memory CD4 and CD8 T cell frequencies responsive to M. leprae whole-cell sonicate was observed in most contacts. Of note, higher frequencies of CD4+ T cells that recognize M. leprae specific epitopes were also detected. Moreover, increased production of the inflammatory mediators IL1-β, IL-6, IL-17, TNF, IFN-γ, MIP1-β, and MCP-1 was found at T1. Interestingly, the increment in these parameters was observed even in those contacts that were not BCG vaccinated at T0. This result reinforces the hypothesis that the continuous exposure of HCMB to live M. leprae down regulates the specific cellular immune response against the pathogen. Moreover, our data suggest that BCG vaccination of HCMB induces activation of T cell clones, likely through "trained immunity", that recognize M. leprae specific antigens not shared with BCG as an additional protective mechanism besides the expected boost in cell-mediated immunity by BCG homologues of M. leprae antigens.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em DST-AIDS. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.pt_BR
Palavras clave en InglêsLeprosypt_BR
Palavras clave en InglêsBCG vaccinationpt_BR
Palavras clave en InglêsMycobacterium lepraept_BR
Palavras clave en InglêsSpecific antigenspt_BR
e-ISSN1935-2735
xmlui.metadata.dc.subject.ods03 Saúde e Bem-Estar


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