Author | Coelho Filho, João Carlos | |
Author | Takenami, Iukary | |
Author | Arruda, Sérgio Marcos | |
Access date | 2018-02-26T18:09:00Z | |
Available date | 2018-02-26T18:09:00Z | |
Document date | 2013 | |
Citation | COELHO FILHO, J. C.; TAKENAMI, I.; ARRUDA, S. M. Revisiting the Rich's formula: an update about granulomas in human tuberculosis. Brazilian Journal of Infectious Diseases, v. 17, n. 2, p. 234–238, 2013. | pt_BR |
ISSN | 1413-8670 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/24947 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Fórmula de Rich | pt_BR |
Subject in Portuguese | Tuberculose | pt_BR |
Subject in Portuguese | Imunopatogênese | pt_BR |
Subject in Portuguese | Granuloma | pt_BR |
Subject in Portuguese | Hipersensibilidade | pt_BR |
Title | Revisiting the Rich's formula: an update about granulomas in human tuberculosis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.bjid.2013.01.006 | |
Abstract | The formula proposed by Rich in 1951 explained the formation in a tuberculous lesion in a period that was unknown cellular functions, cytokines and other immunological aspects involved in granuloma formation by tuberculosis; its components are assembled conceptually to explain the pathogenic mechanisms involved in the granulomatous lesion in tuberculosis. In this manuscript, we report an update of Rich's formula based on the new and old concepts about pathogenic mechanisms involved in the granulomatous lesion in tuberculosis. Current knowledge allows us to conclude that the balance between the characteristics of the bacillus and host protective response is necessary to indicate the outcome of pathogenesis, infection or active disease and the necrosis degree of the tuberculosis lesion. | pt_BR |
Affilliation | Fundação José Silveira. Laboratório de Patologia. Salvador, BA, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
Subject | Rich’s formula | pt_BR |
Subject | Tuberculosis | pt_BR |
Subject | Immunopathogenesis | pt_BR |
Subject | Granuloma | pt_BR |
Subject | Hypersensitivity | pt_BR |