Author | Aleluia, Milena Magalhães | |
Author | Guarda, Caroline Conceição da | |
Author | Santiago, Rayra Pereira | |
Author | Fonseca, Teresa Cristina Cardoso | |
Author | Neves, Fábia Idalina | |
Author | Souza, Regiana Quinto de | |
Author | Farias, Larissa Alves | |
Author | Pimenta, Felipe Araújo | |
Author | Fiuza, Luciana Magalhães | |
Author | Pitanga, Thassila Nogueira | |
Author | Ferreira, Júnia Raquel Dutra | |
Author | Adorno, Elisângela Vitória | |
Author | Cerqueira, Bruno Antonio Veloso | |
Author | Gonçalves, Marilda de Souza | |
Access date | 2018-02-27T12:31:07Z | |
Available date | 2018-02-27T12:31:07Z | |
Document date | 2017 | |
Citation | ALELUIA, Milena Magalhães et al. Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia. Lipids in Health and Disease, v. 16, p. 1-9, 2017. | pt_BR |
ISSN | 1476-511X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/24957 | |
Sponsorship | Gonçalo Moniz Institute at the Oswaldo Cruz Foundation (IGM-FIOCRUZ – Bahia - Brazil) (CAAE 08452913.9.0000.0040). | pt_BR |
Language | eng | pt_BR |
Publisher | BioMed Central | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Sub-fenótipo | pt_BR |
Subject in Portuguese | Anemia falciforme | pt_BR |
Subject in Portuguese | Sislipidemia | pt_BR |
Subject in Portuguese | α-talassemia | pt_BR |
Title | Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia | pt_BR |
Type | Article | pt_BR |
DOI | 10.1186/s12944-017-0454-1 | |
Abstract | Sickle cell anemia (SCA) patients exhibit sub-phenotypes associated to hemolysis and vaso-occlusion. The disease has a chronic inflammatory nature that has been also associated to alterations in the lipid profile. This study aims to analyze hematological and biochemical parameters to provide knowledge about the SCA sub-phenotypes previously described and suggest a dyslipidemic sub-phenotype. Methods: A cross-sectional study was conducted from 2013 to 2014, and 99 SCA patients in steady state were enrolled.
We assessed correlations and associations with hematological and biochemical data and investigated the co-inheritance
of -α3.7Kb-thalassemia (-α3.7Kb-thal). Correlation analyses were performed using Spearman and Pearson coefficient. The
median of quantitative variables between two groups was compared using t-test and Mann-Whitney. P-values <0.05
were considered statistically significant.
Results: We found significant association of high lactate dehydrogenase levels with decreased red blood cell count
and hematocrit as well as high levels of total and indirect bilirubin. SCA patients with low nitric oxide metabolites had
high total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol and reduced very
low-density cholesterol, triglycerides, direct bilirubin level and reticulocyte counts. In SCA patients with
high-density lipoprotein cholesterol greater than 40 mg/dL, we observed increased red blood cell count, hemoglobin,
hematocrit, and fetal hemoglobin and decreased nitric oxide metabolites levels. The presence of -α3.7Kb-thal was
associated with high red blood cell count and low mean corpuscular volume, mean corpuscular hemoglobin, platelet
count and total and indirect bilirubin levels.
Conclusions: Our results provide additional information about the association between biomarkers and
co-inheritance of -α3.7Kb-thal in SCA, and suggest the role of dyslipidemia and nitric oxide metabolites in the
characterization of this sub-phenotype. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia e Genética Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia e Genética Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia e Genética Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Centro de Referência a Doença Falciforme de Itabuna. Itabuna, BA, Brasil / Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil. | pt_BR |
Affilliation | Centro de Referência a Doença Falciforme de Itabuna. Itabuna, BA, Brasil. | pt_BR |
Affilliation | Centro de Referência a Doença Falciforme de Itabuna. Itabuna, BA, Brasil / Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia e Genética Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia e Genética Computacional. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia e Genética Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Universidade Estadual da Bahia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Hematologia e Genética Computacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
Subject | Sub-phenotype | pt_BR |
Subject | Sickle cell anemia | pt_BR |
Subject | Dyslipidemia | pt_BR |
Subject | α-thalassemia | pt_BR |