| Autor | Campos, Cecilia Bonolo de | |
| Autor | Damasceno, Karine Araujo | |
| Autor | Gamba, Conrado de Oliveira | |
| Autor | Ribeiro, Ana M | |
| Autor | Machado, Carla Jorge | |
| Autor | Lavalle, Gleidice Eunice | |
| Autor | Cassali, Geovanni Dantas | |
| Data de acesso | 2018-02-27T14:33:36Z | |
| Data de disponibilização | 2018-02-27T14:33:36Z | |
| Data do publicação | 2016 | |
| Citação | CAMPOS, C. B. et al. Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms. Journal of Feline Medicine and Surgery, v. 18, n. 12, p. 1003–1012, 2016. | pt_BR |
| ISSN | 1098-612X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/24968 | |
| Descrição | DAMASCENO, Karine Araújo. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
| Fomento | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Coordenacão de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento e Pesquisa (CNPq) and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG). | pt_BR |
| Idioma | eng | pt_BR |
| Editor | SAGE Publications | pt_BR |
| Direito Autoral | open access | pt_BR |
| Palavras-chave | Neoplasia maligna | pt_BR |
| Palavras-chave | Neoplasias mamárias | pt_BR |
| Palavras-chave | Metástase linfática | pt_BR |
| Palavras-chave | Prognostico | pt_BR |
| Palavras-chave | Animais | pt_BR |
| Título | Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms | pt_BR |
| Tipo do documento | Article | pt_BR |
| DOI | 10.1177/1098612X15610367 | |
| Resumo em Inglês | The aim of the study was to investigate prognostic factors in feline mammary gland neoplasms, correlating them with overall survival (OS). Objectives The aim of the study was to investigate prognostic factors in feline mammary gland neoplasms,
correlating them with overall survival (OS).
Methods Fifty-six primary malignant mammary gland neoplasms and 16 metastatic lymph nodes from 37 female
cats were analyzed. Clinical staging, histologic type and grade, and immunohistochemistry for Ki-67, progesterone
and estrogen receptor, human epidermal growth factor receptor type 2 (HER-2), cyclooxygenase-2 (COX-2) and
vascular endothelial growth factor (VEGF) were evaluated. Follow-up was performed in order to correlate prognostic
factors with OS.
Results Lymph node metastasis was found in 35% of cases. Clinical stage III, tubulopapillary carcinomas and
histologic grade II cases prevailed in the study. Most neoplasms were positive for hormonal receptors, negative
for HER-2 overexpression and presented VEGF overexpression. Immunoreactivity for Ki-67 (P = 0.046) and COX-2
(P = 0.007) was higher in metastases than in primary tumors. COX-2 (P = 0.089), HER-2 (P = 0.012) and histologic
grade (P = 0.080) were correlated with OS.
Conclusions and relevance The data suggest that inhibition of ovarian hormones and COX-2 may represent a
therapeutic option for malignant feline mammary gland neoplasms. When evaluating disease progression, COX-2
scores and Ki-67 index should be analyzed in primary tumors and metastases. histologic grade, HER-2 status and
COX-2 scores were found to have a direct influence on OS. Prognostic factors allow for a better understanding of
disease outcome in a condition that is characterized by a poor prognosis. The present work highlights the need for
further studies on endocrine therapy and COX-2 inhibitors, which could influence OS. | pt_BR |
| Afiliação | Veterinary Sciences of the Sao Paulo State University. School of Agricultural. Department of Veterinary Clinic and Surgery. Jaboticabal, SP, Brazil / Federal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, Brazil | pt_BR |
| Afiliação | Federal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, Brazil | pt_BR |
| Afiliação | Federal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, Brazil | pt_BR |
| Afiliação | Federal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, Brazil | pt_BR |
| Afiliação | Federal University of Minas Gerais. Faculty of Medicine. Department of Preventive and Social Medicine. Belo Horizonte, MG, Brazil | pt_BR |
| Afiliação | Federal University of Minas Gerais. Veterinary Hospital. Veterinary School. Belo Horizonte, MG, Brazil | pt_BR |
| Afiliação | Federal University of Minas Gerais. Laboratory of Comparative Pathology. Department of General Pathology. Belo Horizonte, MG, Brazil | pt_BR |
| Palavras-chave em inglês | Malignant neoplasms | pt_BR |
| Palavras-chave em inglês | Breast neoplasm | pt_BR |
| Palavras-chave em inglês | Lymphatic Metastasis | pt_BR |
| Palavras-chave em inglês | Prognosis | pt_BR |
| Palavras-chave em inglês | Animals | pt_BR |
