| Author | Barbosa, Marília Imaculada Frazão | |
| Author | Correa, Rodrigo de Sousa | |
| Author | Bastos, Tanira Matutino | |
| Author | Pozzi, L. V. | |
| Author | Moreira, Diogo Rodrigo de Magalhães | |
| Author | Ellena, Javier Alcides | |
| Author | Doriguetto, Antonio Carlos | |
| Author | Silveira, Rafael Gomes da | |
| Author | Oliveira, C. R. | |
| Author | Kuznetsov, Aleksey Evgenyevich | |
| Author | Malta, Valeria Rodrigues dos Santos | |
| Author | Soares, Milena Botelho Pereira | |
| Author | Batista, Alzir Azevedo | |
| Access date | 2018-02-28T13:51:37Z | |
| Available date | 2018-02-28T13:51:37Z | |
| Document date | 2017 | |
| Citation | BARBOSA, Marília Imaculada Frazão et al. Structural isomerism of Ru(II)-carbonyl complexes: synthesis, characterization and their antitrypanosomal activities. New Journal of Chemistry, v. 41, p. 4468-4477, 2017. | pt_BR |
| ISSN | 1144-0546 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/24995 | |
| Sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Processo 2014/10516-7) and Fundação de Amparo a` Pesquisa do Estado da Bahia (FAPESB, grant PET0042/2013 and PRONEX PNX0002/2014). | pt_BR |
| Language | eng | pt_BR |
| Publisher | Royal Society of Chemistry | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Compostos de rutênio | pt_BR |
| Subject in Portuguese | Isomerismo | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Cristalografia por raios X | pt_BR |
| Subject in Portuguese | Farmacologia | pt_BR |
| Subject in Portuguese | Produtos quimicos | pt_BR |
| Title | Structural isomerism of Ru(II)-carbonyl complexes: synthesis, characterization and their antitrypanosomal activities | pt_BR |
| Type | Article | |
| DOI | 10.1039/C7NJ00125H | pt_BR |
| Abstract | New complexes with the general formula [RuCl(CO)(dppb)(diimine)]PF6, [dppb = 1,4-bis(diphenylphosphino) butane; diimine = 2,20-bipyridine (bipy) or 1,10-phenanthroline (phen)], were prepared. Thus, the complexes ct-[RuCl(CO)(dppb)(bipy)]PF6 (1), ct-[RuCl(CO)(dppb)(phen)]PF6 (2), tc-[RuCl(CO)(dppb)(bipy)]PF6 (3), tc-[RuCl(CO)(dppb)(phen)]PF6 (4), cc-[RuCl(CO)(dppb)(bipy)]PF6 (5) and cc-[RuCl(CO)(dppb)(phen)]PF6
(6) were obtained and characterized. In this case, the first letter in the prefixes indicates the position of CO with respect to the chlorido ligand and the second one is related to the phosphorus atoms. The compositions
of the complexes were confirmed by analytical techniques and an octahedral environment around the ruthenium was confirmed by single-crystal X-ray diffraction of the complexes ct-[RuCl(CO)(dppb)(bipy)]PF6 and cc-[RuCl(CO)(dppb)(phen)]PF6. The oxidation potentials of the complexes were determined by cyclic voltammetry and it was found that they vary according to the CO position in the complexes. In order to obtain
information on the stability of the ct, tc and cc-[RuCl(CO)(dppb)(bipy)]PF6 (1), (3) and (5) isomers, computational studies were carried out, and they showed large differences between the HOMO/LUMO energies. As
monitored by 13C NMR, the stability of the complexes with respect to CO displacement, for at least 72 h, in DMSO-d6 solution, is independent of the CO position in the complexes. Pharmacological evaluation of the complexes against the Trypanosoma cruzi parasite revealed the structure–activity relationships, showing that the presence and position of the CO ligand in the complexes are relevant for the antiparasitic activity of the
compounds. The most active compound, the tc-[RuCl(CO)(dppb)(bipy)]PF6 isomer, presented potent antiparasitic activity, which was achieved by causing oxidative stress followed by parasite cell death through necrosis. Thus, the findings presented here demonstrate that the use of a carbonyl ligand provides stability and pharmacological properties to ruthenium/diphosphine/diimine complexes. | pt_BR |
| Affilliation | Universidade Federal de Alfenas. Instituto de Química. Alfenas, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Química. Ouro Preto, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Física de São Carlos. São Carlos, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Alfenas. Instituto de Química. Alfenas, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brazil / Instituto Federal Goiano. Ceres, GO, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São Carlos. Departamento de Química. São Carlos, SP, Brasil. | pt_BR |
| Subject | Ruthenium complex | pt_BR |
| Subject | isomerism | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | X-Ray crystallography | pt_BR |
| Subject | Pharmacology | pt_BR |
| Subject | Chemicals | pt_BR |
