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AutorCarvalho, Viviane do Carmo Vasconcelos de
AutorSilva, Lílian Caroliny Amorim
AutorWerkhauser, Roberto Pereira
AutorMontenegro, Sérgio Tavares
AutorSilva, Carlos Gustavo Regis da
AutorGomes, Adriana Vieira
AutorMorais, Clarice Neuenschwander Lins de
AutorMontenegro, Silvia Maria Lucena
Fecha de acceso2018-02-28T15:57:11Z
Fecha de disponibilización2018-02-28T15:57:11Z
Fecha de publicación2016
ReferenciaCARVALHO, V. C. V. et al. Evaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazil. International Journal of Cardiovascular Sciences, v. 29, n. 4, p. 288-294, 2016.pt_BR
ISSN2359-4802pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/24999
PromociónProep APQ 1620 4.01/15.pt_BR
Idiomaengpt_BR
EditorSociedade de Cardiologia do Estado do Rio de Janeiropt_BR
Derechos de autoropen accesspt_BR
Palabras clave en PortuguésSíndrome coronariana agudapt_BR
Palabras clave en PortuguésIsquemia do miocárdiopt_BR
Palabras clave en PortuguésPolimorfismo, genéticopt_BR
Palabras clave en PortuguésInterleucina-6pt_BR
TítuloEvaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazilpt_BR
Tipo del documentoArticlept_BR
Resumen en InglésBackground: Acute coronary syndrome (ACS) is a leading cause of morbidity and mortality worldwide. It is a multifactorial disease caused by obstruction of the coronary arteries by atheromatous plaques and leads to heart ischemia. Several studies suggest that some genetic polymorphisms change the cytokines levels and influence ACS development.Objective: In this study, we evaluated the IL-6 (-174G/C) polymorphism, serum levels of cytokine and its relationship with ACS and the thrombolysis in myocardial infarction (TIMI) risk score. Materials and Methods: A sample of 200 patients with ACS [TIMI risk – Low (70); Intermediate (89); High (41)] in Brazilian population was used. Genotyping was carried out by polymerase chain reaction, followed by DNA sequencing. Results: There was no significant differences in genotype (p = 0.53) and allele (p = 0.32) distributions between ACS patient and without ACS patients groups on IL-6 allelic polymorphism and between the three differents TIMI risk score (p > 0.05). Moreover IL-6 polymorphism did not affect the cytokine levels and these levels were not related to TIMI score. Conclusions: With these results, we suggest that the IL-6 (-174 G/C) polymorphism, until now, is not related to ACS and did not change the levels of the cytokine in studied population. Further studies with different populations should be done to verify those results. It is important to emphasize that, since ACS is a multifactorial disease, other risk factors and other pro-inflammatory cytokines should be assessed to better understand this pathology.pt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasilpt_BR
AfiliaciónReal Hospital Português. Real Hospital do Coração. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Biologia Parasitária. Salvador, BA, Brasilpt_BR
AfiliaciónUniversidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brasilpt_BR
Palavras clave en InglêsAcute Coronary Syndromept_BR
Palavras clave en InglêsMyocardial Ischemiapt_BR
Palavras clave en InglêsPolymorphism, Geneticpt_BR
Palavras clave en InglêsInterleukin-6pt_BR


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