| Author | Jorge, Natasha Andressa Nogueira | |
| Author | Wajnberg, Gabriel | |
| Author | Ferreira, Carlos Gil | |
| Author | Carvalho, Benilton de Sá | |
| Author | Passetti, Fabio | |
| Access date | 2018-03-01T11:23:23Z | |
| Available date | 2018-03-01T11:23:23Z | |
| Document date | 2017 | |
| Citation | JORGE, Natasha Andressa Nogueira; et al. snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma. Plos One, v.12, n.8, e0183410, 8p, Aug. 2017. | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25006 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | |
| Subject in Portuguese | RNA Nucleolar Pequeno | pt_BR |
| Subject in Portuguese | RNA Interferente Pequeno | pt_BR |
| Subject in Portuguese | Tabaco | pt_BR |
| Subject in Portuguese | Mulheres | pt_BR |
| Subject in Portuguese | Adenocarcinoma | pt_BR |
| Subject in Portuguese | Pulmão | pt_BR |
| Title | snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0183410 | |
| Abstract | Lung cancer is one of the most frequent types of cancer worldwide. Most patients are diagnosed at advanced stage and thus have poor prognosis. Smoking is a risk factor for lung cancer, however most smokers do not develop lung cancer while 20% of women with lung adenocarcinoma are non-smokers. Therefore, it is possible that these two groups present differences besides the smoking status, including differences in their gene expression signature. The altered expression patterns of non-coding RNAs in complex diseases make them potential biomarkers for diagnosis and treatment. We analyzed data from differentially and constitutively expressed PIWI-interacting RNAs and small nucleolar RNAs from publicly available small RNA high-throughput sequencing data in search of an expression pattern of non-coding RNA that could differentiate these two groups. Here, we report two sets of differentially expressed small non-coding RNAs identified in normal and tumoral tissues of women with lung adenocarcinoma, that discriminate between smokers and non-smokers. Our findings may offer new insights on metabolic alterations caused by tobacco and may be used for early diagnosis of lung cancer. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Instituto D`Or de pesquisa e Educação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Estadual de Campinas. Departamento de Estatística. Campinas, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | lung adenocarcinoma | pt_BR |
| Subject | Women | pt_BR |
| Subject | tobacco | pt_BR |
| Subject | snoRNA | pt_BR |
| Subject | snoRNA | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
