| Author | Fernandes, Rafaela Sachetto | |
| Author | Barbosa, Tereza Cristina | |
| Author | Barbosa, Mayra Mara Ferrari | |
| Author | Miyasato, Patrícia Aoki | |
| Author | Nakano, Eliana | |
| Author | Leite, Luciana Cezar Cerqueira | |
| Author | Farias, Leonardo Paiva | |
| Access date | 2018-03-01T12:36:22Z | |
| Available date | 2018-03-01T12:36:22Z | |
| Document date | 2017 | |
| Citation | FERNANDES, R. S. et al. Stage and tissue expression patterns of Schistosoma mansoni venom allergen-like proteins SmVAL 4, 13, 16 and 24. Parasites & Vectors, v. 10, p. 223, 2017. | pt_BR |
| ISSN | 1756-3305 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25011 | |
| Sponsorship | Fundação Butantan and Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP - 2012/23124–4) to LCCL and LPF, and by fellowships from FAPESP to RSF (FAPESP -2010/18486-9) and from CAPES to MMFB. | pt_BR |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Glândulas acetabulares | pt_BR |
| Subject in Portuguese | Bola de germo | pt_BR |
| Subject in Portuguese | Glândulas esofágicas | pt_BR |
| Title | Stage and tissue expression patterns of Schistosoma mansoni venom allergen-like proteins SmVAL 4, 13, 16 and 24 | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1186/s13071-017-2144-2 | |
| Abstract | Schistosoma mansoni venom allergen-like protein (SmVAL) is a gene family composed of 29 members divided into group 1 encoding proteins potentially secreted, and group 2 encoding intracellular components. Some members were found to be upregulated in the transition of germ ball - cercariae - day 3 schistosomula, suggesting that group 1 SmVAL proteins are associated with the invasion of the human host, although their functions are not completely established. Recently, we have described the localization of SmVAL7 (group 1) and SmVAL6 (group 2) transcripts in the oesophageal gland and in the oral and ventral suckers of adult parasites, respectively. The expression patterns of the two genes suggest that SmVAL7 protein plays a role in the blood-feeding process while SmVAL6 is associated with the parasite attachment and movement in the vasculature. In this way, searching for additional secreted SmVAL proteins that could be involved in key processes from skin penetration to the beginning of blood-feeding, we investigated the tissue localization of SmVAL4, 13, 16 and 24 by whole-mount in situ hybridization (WISH). | pt_BR |
| Affilliation | Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil / Universidade de São Paulo. Pós-Graduação Interunidades em Biotecnologia. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil / Universidade de São Paulo. Pós-Graduação Interunidades em Biotecnologia. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Instituto Butantan. Laboratorio de Parasitologia. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Instituto Butantan. Laboratorio de Parasitologia. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Subject | SmVAL | pt_BR |
| Subject | WISH | pt_BR |
| Subject | Acetabular glands | pt_BR |
| Subject | Germ ball | pt_BR |
| Subject | Oesophageal glands | pt_BR |
