| Author | Fonseca, Erica L. | |
| Author | Marin, Michel A. | |
| Author | Freitas, Fernanda S. | |
| Author | Vitório, Bruna S. A. | |
| Author | Araújo, Flávio M. G. de | |
| Author | Camargo, Dhian R. A. | |
| Author | Coimbra, Roney S. | |
| Author | De Filippis, Ivano R. | |
| Author | Vicente, Ana Carolina P. | |
| Access date | 2018-03-01T16:08:37Z | |
| Available date | 2018-03-01T16:08:37Z | |
| Document date | 2017 | |
| Citation | FONSECA, Érica L. et al. The invasive MenC cc103 lineage with penicillin reduced susceptibility persisting in Brazil. International Journal of Medical Microbiology,v.307, p.287–290, 2017. | pt_BR |
| ISSN | 1438-4221 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25018 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Neisseria meningitidis | pt_BR |
| Subject in Portuguese | Aptidão Genética | pt_BR |
| Subject in Portuguese | Penicilina | pt_BR |
| Subject in Portuguese | Complexo clonal ST-103 | pt_BR |
| Title | The invasive MenC cc103 lineage with penicillin reduced susceptibility persisting in Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.ijmm.2017.05.004 | |
| Abstract | Penicillin is the antibiotic of choice for the treatment of meningococcal infections, and mutations in penA gene are involved with reduced susceptibility (penI) emergence to this antibiotic. This study aimed to characterize the penA allelic diversity, their association with penIphenotype and distribution among prevalent meningococci serogroups in Brazil. The entire penA from 49 invasive strains of distinct serogroups circulating in Brazil for more than two decades were obtained by PCR and sequencing. Additionally, the penA from 22 publicly available complete Neisseria meningitidis genomes from Brazil were included in the study. The allelic diversity was determined and a genetic tree was built using the penA sequence alignment. The penicillin MIC was obtained by the E-Test method. In general, the identified penA alleles correlated with the observed penIphenotype. The canonical penA1 was the most prevalent allele, however, several altered penA were also identified in strains presenting increased penicillin MICs. It was identified a new penA amino acid position (residue 480) that possibly influence the penicillin MIC in some strains. Interestingly, the altered penA14 was found in penIinvasive MenC cc103 strains spread in Brazil and persisting since 2011, indicating that the biological cost imposed by penIphenotype can be ameliorated by particular features present in this lineage, which represents an additional public health threat. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Ezequiel Dias. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Informática de Biossistemas. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Neurogenômica. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Altered penA | pt_BR |
| Subject | Penicillin reduced susceptibility | pt_BR |
| Subject | ST-103 clonal complex | pt_BR |
| Subject | Neisseria meningitidis | pt_BR |
| Subject | Fitness | pt_BR |
| e-ISSN | 1618-0607 | |
| Embargo date | 2030-01-01 | |
