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AutorMaretti-Mira, A. C.
AutorOliveira Neto, M. P. de
AutorCruz, A. M. da
AutorOliveira, M. P. de
AutorCraft, N.
AutorPirmez, C.
Fecha de acceso2018-03-08T15:59:21Z
Fecha de disponibilización2018-03-08T15:59:21Z
Fecha de publicación2011
ReferenciaMARETTI-MIRA, A. C. et al. Therapeutic failure in American cutaneous leishmaniasis is associated with gelatinase activity and cytokine expression. Clinical and Experimental Immunology, v. 163, p. 207-214, 2010.pt_BR
ISSN0009-9104pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/25196
Idiomaengpt_BR
EditorWileypt_BR
Derechos de autorrestricted access
Palabras clave en PortuguésCitocinaspt_BR
Palabras clave en PortuguésLeishmaniose tegumentar americanapt_BR
Palabras clave en PortuguésMetaloproteinases da Matrizpt_BR
Palabras clave en PortuguésImunologia da Leishmaniosept_BR
Palabras clave en PortuguésFalha terapêuticapt_BR
TítuloTherapeutic failure in American cutaneous leishmaniasis is associated with gelatinase activity and cytokine expressionpt_BR
Tipo del documentoArticle
DOI10.1111/j.1365-2249.2010.04285.x
Resumen en InglésCutaneous lesions caused by Leishmania braziliensis infection occasionally heal spontaneously, but with antimonials therapy heal rapidly in approximately 3 weeks. However, about 15% of the cases require several courses of therapy. Matrix metalloproteinase-2 (MMP-2) and MMP-9 are gelatinases that have been implicated in other chronic cutaneous diseases and skin re-epithelialization. These enzymes are controlled by their natural inhibitors [tissue inhibitors of metalloproteinase (TIMPs)] and by some cytokines. Uncontrolled gelatinase activity may result in intense tissue degradation and, consequently, poorly healing wounds. The present study correlates gelatinase activity to therapeutic failure of cutaneous leishmaniasis (CL) lesions. Our results demonstrate an association between gelatinase activity and increased numbers of cells making interferon (IFN)-γ, interleukin (IL)-10 and transforming growth factor (TGF)-β in lesions from poor responders. Conversely, high levels of MMP-2 mRNA and enhanced MMP-2 : TIMP-2 ratios were associated with a satisfactory response to antimonials treatment. Additionally, high gelatinolytic activity was found in the wound beds, necrotic areas in the dermis and within some granulomatous infiltrates. These results indicate the importance of gelatinase activity in the skin lesions caused by CL. Thus, we hypothesize that the immune response profile may be responsible for the gelatinase activity pattern and may ultimately influence the persistence or cure of CL lesions.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Divisions of Dermatology and Adult Infectious Disease. Department of Medicine. Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center. Torrance, CA, USA.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónDivisions of Dermatology and Adult Infectious Disease. Department of Medicine. Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center. Torrance, CA, USA.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil.pt_BR
Palavras clave en InglêsLeishmaniasis immunologypt_BR
Palavras clave en InglêsCytokinespt_BR
Palavras clave en InglêsAmerican tegumentary leishmaniasispt_BR
Palavras clave en InglêsMatrix metalloproteinasespt_BR
Palavras clave en InglêsTherapeutic failurept_BR
e-ISSN1365-2249
Fecha de embargo2030-01-01


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