| Author | Mehta, Ravi | |
| Author | Soares, Cristiane Nascimento | |
| Author | Medialdea-Carrera, Raquel | |
| Author | Ellul, Mark | |
| Author | Silva, Marcus Tulius Texeira da | |
| Author | Rosala-Hallas, Anna | |
| Author | Jardim, Marcia Rodrigues | |
| Author | Burnside, Girvan | |
| Author | Pamplona, Luciana | |
| Author | Bhojak, Maneesh | |
| Author | Manohar, Radhika | |
| Author | Silva, Gabriel Amorelli Medeiros da | |
| Author | Adriano, Marcus Vinicius | |
| Author | Brasil, Patrícia | |
| Author | Nogueira, Rita Maria Ribeiro | |
| Author | Santos, Carolina Cardoso dos | |
| Author | Turtle, Lance | |
| Author | Sequeira, Patricia Carvalho de | |
| Author | Brown, David W. | |
| Author | Griffiths, Michael J. | |
| Author | Filippis, Ana Maria Bispo de | |
| Author | Solomon, Tom | |
| Access date | 2018-03-13T12:30:51Z | |
| Available date | 2018-03-13T12:30:51Z | |
| Document date | 2018 | |
| Citation | MEHTA, Ravi et al. The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: a case series. PLoS Neglected Tropical Diseases, v. 12, n. 2, p. 1-20, Feb. 2018. | pt_BR |
| ISSN | 1935-2727 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25269 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Zika virus | pt_BR |
| Subject in Portuguese | Chikungunya virus | pt_BR |
| Subject in Portuguese | Rio de Janeiro | pt_BR |
| Subject in Portuguese | Adultos | pt_BR |
| Subject in Portuguese | Doenças neurológicas | pt_BR |
| Title | The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: a case series | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pntd.0006212 | |
| Abstract | Background: During 2015–16 Brazil experienced the largest epidemic of Zika virus ever reported. This arthropod-borne virus (arbovirus) has been linked to Guillain-Barre´ syndrome (GBS) in adults but other neurological associations are uncertain. Chikungunya virus has caused outbreaks in Brazil since 2014 but associated neurological disease has rarely been reported here. We investigated adults with acute neurological disorders for Zika, chikungunya and dengue, another arbovirus circulating in Brazil.
Methods: We studied adults who had developed a new neurological condition following suspected Zika virus infection between 1st November 2015 and 1st June 2016. Cerebrospinal fluid (CSF), serum, and urine were tested for evidence of Zika, chikungunya, and dengue viruses. Results: Of 35 patients studied, 22 had evidence of recent arboviral infection. Twelve had positive PCR or IgM for Zika, five of whom also had evidence for chikungunya, three for dengue, and one for all three viruses. Five of them presented with GBS; seven had presentations other than GBS, including meningoencephalitis, myelitis, radiculitis or combinations of these syndromes. Additionally, ten patients positive for chikungunya virus, two of whom also had evidence for dengue virus, presented with a similar range of neurological conditions. Conclusions: Zika virus is associated with a wide range of neurological manifestations, including central nervous system disease. Chikungunya virus appears to have and equally important association with neurological disease in Brazil, and any patients had dual infection. To understand fully the burden of Zika we must look beyond GBS, and also investigate for other co-circulating arboviruses, particularly chikungunya. | pt_BR |
| Affilliation | University of Liverpool. National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool, United Kingdom / University of Liverpool, Institute of Infection and Global Health. Liverpool, United Kingdom. | pt_BR |
| Affilliation | Hospital Federal dos Servidores do Estado. Departamento de Neurologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | University of Liverpool. National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool, United Kingdom / University of Liverpool, Institute of Infection and Global Health. Liverpool, United Kingdom. | pt_BR |
| Affilliation | University of Liverpool. National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool, United Kingdom / University of Liverpool, Institute of Infection and Global Health. Liverpool, United Kingdom / Walton Centre NHS Foundation Trust. Department of Neurology. Liverpool, United Kingdom. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Neuroinfecção. Rio de Janeiro, RJ. Brasil / Hospital de Clínicas de Niterói. Departamento de Neurologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | University of Liverpool. Institute of Translational Medicine. Department of Biostatistics. Liverpóol, United Kingdom. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Liverpool. Institute of Translational Medicine. Department of Biostatistics. Liverpóol, United Kingdom. | pt_BR |
| Affilliation | Hospital Geral de Bonsucesso. Departamento de Neurologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Walton Centre NHS Foundation Trust. Department of Neurology. Liverpool, United Kingdom. | pt_BR |
| Affilliation | Walton Centre NHS Foundation Trust. Department of Neurology. Liverpool, United Kingdom. | pt_BR |
| Affilliation | Hospital Federal dos Servidores do Estado. Departamento de Neurologia. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Hospital Barra D'or. Departamento de Neurologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | University of Liverpool. National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool, United Kingdom / University of Liverpool, Institute of Infection and Global Health. Liverpool, United Kingdom / Walton Centre NHS Foundation Trust. Department of Neurology. Liverpool, United Kingdom. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e de Sarampo. Rio de Janeiro, RJ, Brasil / Public Health England. National Infection Service. Virus Reference Department. London, United Kingdom. | pt_BR |
| Affilliation | University of Liverpool. National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool, United Kingdom / University of Liverpool, Institute of Infection and Global Health. Liverpool, United Kingdom / Alder Hey Children's NHS Foundation Trust. Department of Neurology. Liverpool, United Kingdom. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | University of Liverpool. National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool, United Kingdom / University of Liverpool, Institute of Infection and Global Health. Liverpool, United Kingdom / Walton Centre NHS Foundation Trust. Department of Neurology. Liverpool, United Kingdom. | pt_BR |
| Subject | Zika virus | pt_BR |
| Subject | Vírus Chikungunya | pt_BR |
| Subject | Rio de Janeiro | pt_BR |
| Subject | Adults | pt_BR |
| Subject | Neurological disease | pt_BR |
| e-ISSN | 1935-2735 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
