| Author | Souza, Marcus Vinícius Dias | |
| Author | Santos, Renan Martins dos | |
| Author | Cerávolo, Isabela Penna | |
| Author | Cosenza, Gustavo | |
| Author | Marçal, Pedro Henrique Ferreira | |
| Author | Figueiredo, Flávio Junior Barbosa | |
| Access date | 2018-03-13T14:00:01Z | |
| Available date | 2018-03-13T14:00:01Z | |
| Document date | 2018 | |
| Citation | SOUZA, Marcus Vinícius Dias et al. Euterpe oleracea pulp extract: Chemical analyses, antibiofilm activity against Staphylococcus aureus, cytotoxicity and interference on the activity of antimicrobial drugs. Microb Pathog., v. 114, p. 29-35, 2018. | pt_BR |
| ISSN | 0882-4010 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25273 | |
| Language | eng | pt_BR |
| Publisher | Academic Press | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | antibioticos | pt_BR |
| Subject in Portuguese | acai | pt_BR |
| Subject in Portuguese | Staphylococcus | pt_BR |
| Title | Euterpe oleracea pulp extract: Chemical analyses, antibiofilm activity against Staphylococcus aureus, cytotoxicity and interference on the activity of antimicrobial drugs | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.micpath.2017.11.006 | |
| Abstract | Euterpe oleracea (Açaí) fruit are widely consumed at the Brazilian Amazon region, and biological potentials such as immunomodulatory and antioxidant have been described for its extracts. However, its antimicrobial properties remain poorly investigated. Here, the antimicrobial and antibiofilm activities of the methanolic extract of an artisanally-manufactured açaí pulp (MEAP) were evaluated against clinical isolates of Staphylococcus aureus. Besides, MEAP interference on the activity of antimicrobial drugs of clinical relevance was explored, and its cytotoxicity against hepatocellular carcinoma cells (HepG2) was investigated. Biochemical and physicochemical properties of the pulp were investigated, and the presence of polyphenols on the extract was confirmed. For the first time, we report that the methanolic extract of açaí pulp is effective against planktonic cells and biofilms of S. aureus, and also decreased the proliferation of HepG2 cells. Statistically significant synergism was observed when the extract was combined to the tested antimicrobials except for erythromycin, and all biochemical and physicochemical parameters ranged within the accepted values established by the Brazilian legislation. Our data open doors for more studies on the antimicrobial activity of phytomolecules isolated from Euterpe oleracea extracts, and also for its combined use with antimicrobial drugs. | pt_BR |
| Affilliation | Universidade Vale do Rio Doce. Faculdade de Ciências da Saúde. Brazil/ Grupo de Pesquisas de Farmalocologia Integrada e Interaçoes de Medicamentos. MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte, MG, Brasil / Grupo de Pesquisas de Farmalocologia Integrada e Interaçãoes de Medicamentos. MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Belo Horizonte, MG, Brasil | pt_BR |
| Affilliation | Universidade Vale do Rio Doce. Faculdade de Ciências da Saúde. Brazil/Grupo de Pesquisas de Farmalocologia Integrada e Interaçoes de Medicamentos. MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil/Instituto Santo Agostinho. Faculdade de Saude e Desenvolvimento Humano. Brazil/Grupo de Pesquisas de Farmalocologia Integrada e Interaçãoes de Medicamentos. MG, Brazil | pt_BR |
| Subject | Antimicrobial | pt_BR |
| Subject | Cytotoxicity | pt_BR |
| Subject | Euterpe oleracea | pt_BR |
| Subject | Staphylococcus | pt_BR |
| Embargo date | 2025-01-01 | |
