| Author | Souza, Thiago Moreno L. | |
| Author | Salluh, Jorge I. F. | |
| Author | Bozza, Fernando A. | |
| Author | Mesquita, Milene | |
| Author | Soares, Márcio | |
| Author | Motta, Fernando C. | |
| Author | Pitrowsky, Melissa Tassano | |
| Author | Oliveira, Maria de Lourdes | |
| Author | Mishin, Vasiliy P. | |
| Author | Gubareva, Larissa V. | |
| Author | Whitney, Anne | |
| Author | Rocco, Sandra Amaral | |
| Author | Gonçalves, Vânia Maria C. | |
| Author | Marques, Venceslaine Prado | |
| Author | Velasco, Eduardo | |
| Author | Siqueira, Marilda Agudo Mendonça Teixeira de | |
| Access date | 2018-03-13T17:30:33Z | |
| Available date | 2018-03-13T17:30:33Z | |
| Document date | 2010 | |
| Citation | SOUZA, Thiago Moreno L. et al. H1N1pdm Influenza Infection in Hospitalized Cancer Patients: Clinical Evolution and Viral Analysis. PLoS ONE, v. 5, n. 11, p.1-10, Nov. 2010. | pt_BR |
| ISSN | 1932-6203 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25292 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Pacientes com câncer | pt_BR |
| Subject in Portuguese | Hospitalizados | pt_BR |
| Subject in Portuguese | Análise viral | pt_BR |
| Subject in Portuguese | Evolução clínica | pt_BR |
| Subject in Portuguese | Vírus pandêmico da gripe A | pt_BR |
| Title | H1N1pdm influenza infection in hospitalized cancer patients: clinical evolution and viral analysis | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0014158 | |
| Abstract | Background: The novel influenza A pandemic virus (H1N1pdm) caused considerable morbidity and mortality worldwide in 2009. The aim of the present study was to evaluate the clinical course, duration of viral shedding, H1N1pdm evolution and emergence of antiviral resistance in hospitalized cancer patients with severe H1N1pdm infections during the winter of 2009
in Brazil. Methods: We performed a prospective single-center cohort study in a cancer center in Rio de Janeiro, Brazil. Hospitalized patients with cancer and a confirmed diagnosis of influenza A H1N1pdm were evaluated. The main outcome measures in this study were in-hospital mortality, duration of viral shedding, viral persistence and both functional and molecular analyses of H1N1pdm susceptibility to oseltamivir. Results: A total of 44 hospitalized patients with suspected influenza-like illness were screened. A total of 24 had diagnosed H1N1pdm infections. The overall hospital mortality in our cohort was 21%. Thirteen (54%) patients required intensive care. The median age of the studied cohort was 14.5 years (3–69 years). Eighteen (75%) patients had received chemotherapy in the previous month, and 14 were neutropenic at the onset of influenza. A total of 10 patients were evaluated for their duration of viral shedding, and 5 (50%) displayed prolonged viral shedding (median 23, range = 11–63 days); however, this was not associated with the emergence of a resistant H1N1pdm virus. Viral evolution was observed in sequentially collected samples. Conclusions: Prolonged influenza A H1N1pdm shedding was observed in cancer patients. However, oseltamivir resistance was not detected. Taken together, our data suggest that severely ill cancer patients may constitute a pandemic virus reservoir with major implications for viral propagation. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital de Câncer. Unidade de Cuidados Intensivos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisas Evandro Chagas. Unidade de Cuidados Intensivos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital de Câncer. Unidade de Cuidados Intensivos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital de Câncer. Unidade de Cuidados Intensivos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Centers for Disease Control. National Center for Immunization and Respiratory Diseases. Influenza Division. Atlanta, Georgia, USA. | pt_BR |
| Affilliation | Centers for Disease Control. National Center for Immunization and Respiratory Diseases. Influenza Division. Atlanta, Georgia, USA. | pt_BR |
| Affilliation | Centers for Disease Control. National Center for Immunization and Respiratory Diseases. Influenza Division. Atlanta, Georgia, USA. | pt_BR |
| Affilliation | Hospital de Câncer. Unidade de Cuidados Intensivos Pediátricos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital de Câncer. Departamento de Doenças Infecciosas. Comitê de Controle de Infecções. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Hospital de Câncer. Departamento de Doenças Infecciosas. Comitê de Controle de Infecções. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Hospital de Câncer. Departamento de Doenças Infecciosas. Comitê de Controle de Infecções. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Cancer Patients | pt_BR |
| Subject | Hospitalized | pt_BR |
| Subject | Influenza A pandemic virus | pt_BR |
| Subject | Clinical Evolution | pt_BR |
| Subject | Viral Analysis | pt_BR |
