| Author | Gómez, Mariela Martínez | |
| Author | Mendonça, Marcos César Lima de | |
| Author | Volotão, Eduardo de Mello | |
| Author | Tort, Luis Fernando López | |
| Author | Silva, Marcelle Figueira Marques da | |
| Author | Cristina, Juan | |
| Author | Leite, José Paulo Gagliardi | |
| Access date | 2018-03-15T16:57:10Z | |
| Available date | 2018-03-15T16:57:10Z | |
| Document date | 2011 | |
| Citation | GÓMEZ, Mariela Martinez; et al. Rotavirus A Genotype P[4]G2: Genetic Diversity and Reassortment Events Among Strains Circulating in Brazil Between 2005 and 2009. Journal of Medical Virology, v.83, p.1093-1106, 2011. | pt_BR |
| ISSN | 0146-6615 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25327 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Rotavirus A | pt_BR |
| Subject in Portuguese | variabilidade genética | pt_BR |
| Subject in Portuguese | Análise filogenética | pt_BR |
| Title | Rotavirus A genotype P[4]G2: genetic diversity and reassortment events among strains circulating in Brazil between 2005 and 2009 | pt_BR |
| Type | Article | |
| DOI | 10.1002/jmv.22071 | |
| Abstract | Group A rotaviruses (RV-A) are the leading cause of severe gastroenteritis in infants and young children worldwide. Due to the epidemiologic complexity of RV-A, especially in developing countries, it is important to determine which genotypes are circulating, principally after the introduction in March 2006 of the monovalent (P[8]G1) Rotarix® vaccine in Brazil by the National Immunization Program. In Phase III trials with Rotarix®, the prevalence of genotype P[4]G2 was extremely low, and therefore, evaluation of heterotypic immunization against this genotype was performed by meta-analysis statistics tests. Different studies have shown the re-emergence of genotype P[4]G2 in Brazil, since 2005, as well as in other countries, suggesting that it could be a continental phenomenon related to the temporal variability in the genotype's naturally occurring distribution. It is important to note that genotype P[4]G2 does not share VP4 or VP7 antigens with the vaccine strain. Therefore, we performed a phylogenetic analysis based on VP4 (VP8), VP7, VP6, and NSP4 genes of RV-A genotype P[4]G2 samples isolated from the five regions of Brazil between 2005 and 2009. This study revealed that different genetic variants of RV-A genotype P[4]G2 circulated in Brazil between 2005 and 2009, and that this variability is determined mainly by: occurrence of point mutations; reassortment events; and widespread global gene flow. The results obtained in this study are important to our understanding of the epidemiology and evolution of RV-A genotype P[4]G2 and demonstrate the importance of continuous monitoring and molecular characterization of RV-A strains circulating in human and animal populations. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | School of Science. Nuclear Research Center. Laboratory of Molecular Virology. Montevideo, Uruguay. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | rotavirus A | pt_BR |
| Subject | P[4]G2 genotype | pt_BR |
| Subject | genetic variability | pt_BR |
| Subject | reassortment | pt_BR |
| Subject | phylogenetic analysis | pt_BR |
| e-ISSN | 1096-9071 | |
| Embargo date | 2030-01-01 | |
