| Author | Valente, Fátima | |
| Author | Lago, Barbara Vieira do | |
| Author | Castro, Carlos Augusto Velasco de | |
| Author | Almeida, Adilson José de | |
| Author | Gomes, Selma A. | |
| Author | Soares, Caroline Cordeiro | |
| Access date | 2018-03-20T11:15:40Z | |
| Available date | 2018-03-20T11:15:40Z | |
| Document date | 2010 | |
| Citation | VALENTE, Fátima; et al. Epidemiology and molecular characterization of hepatitis B virus in Luanda, Angola. Mem Inst Oswaldo Cruz, v.105, n.8, p.970-977, Dec. 2010. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25406 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | HIV-1 | pt_BR |
| Subject in Portuguese | Vírus da Hepatite B | pt_BR |
| Subject in Portuguese | Genótipos | pt_BR |
| Subject in Portuguese | Luanda | pt_BR |
| Title | Epidemiology and molecular characterization of hepatitis B virus in Luanda, Angola | pt_BR |
| Type | Article | pt_BR |
| Abstract | An estimated 360 million people are infected with hepatitis B virus (HBV) worldwide. Among these, 65 million
live in Africa. Despite the high levels of hepatitis B in Africa, HBV epidemiology is still poorly documented in most
African countries. In this work, the epidemiological and molecular characteristics of HBV infection were evaluated
among the staff, visitors and adult patients (n = 508) of a public hospital in Luanda, Angola. The overall prevalence
of hepatitis B core antibody (anti-HBc) and hepatitis B surface antigen was 79.7% and 15.1%, respectively. HBV
infection was higher in males and was more prevalent in individuals younger than 50 years old. HBV-DNA was
detected in 100% of HBV “e” antigen-positive serum samples and in 49% of anti-hepatitis Be antibody-positive
samples. Thirty-five out of the 40 HBV genotypes belonged to genotype E. Circulation of genotypes A (4 samples)
and D (1 sample) was also observed. The present study demonstrates that HBV infection is endemic in Luanda, which
has a predominance of genotype E. This genotype is only sporadically found outside of Africa and is thought to have
emerged in Africa at a time when the trans-Atlantic slave trade had stopped. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil / Ministério da Saúde. Fundação Eduardo dos santos. Angola. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | hepatitis B virus | pt_BR |
| Subject | HBV-DNA | pt_BR |
| Subject | genotypes | pt_BR |
| Subject | HIV-1 | pt_BR |
| Subject | Luanda | pt_BR |
| e-ISSN | 1678-8060 | |
