| Author | Greer, Amy E. | |
| Author | Ou, San-San | |
| Author | Wilson, Ethan | |
| Author | Piwowar-Manning, Estelle | |
| Author | Forman, Michael S. | |
| Author | McCauley, Marybeth | |
| Author | Gamble, Theresa | |
| Author | Ruangyuttikarn, Cholticha | |
| Author | Hosseinipour, Mina C. | |
| Author | Kumarasamy, Nagalingeswaran | |
| Author | Nyirenda, Mulinda | |
| Author | Grinsztejn, Beatriz | |
| Author | Pilotto, Jose Henrique | |
| Author | Kosashunhanan, Natthapol | |
| Author | Melo, Marineide Gonçalves de | |
| Author | Makhema, Joseph | |
| Author | Akelo, Victor | |
| Author | Panchia, Ravindre | |
| Author | Badal-Faesen, Sharlaa | |
| Author | Chen, Ying Q. | |
| Author | Cohen, Myron S. | |
| Author | Eshleman, Susan H. | |
| Author | Thio, Chloe L. | |
| Author | Valsamakis, Alexandra | |
| Access date | 2018-03-21T12:58:13Z | |
| Available date | 2018-03-21T12:58:13Z | |
| Document date | 2017 | |
| Citation | GREER, Amy E. et al. Comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical Trial: HPTN 052. Journal of Acquired Immune Deficiency Syndromes, v. 76, n. 4, p. 388-393, Dec. 2017. | pt_BR |
| ISSN | 1525-4135 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25438 | |
| Language | por | pt_BR |
| Publisher | Lippincott, Williams & Wilkins | pt_BR |
| Rights | open access | |
| Title | Comparison of hepatitis B virus infection in HIV-infected and HIV-uninfected participants enrolled in a multinational clinical Trial: HPTN 052 | pt_BR |
| Type | Article | |
| DOI | 10.1097/QAI.0000000000001511 | |
| Abstract | Objective: Data comparing hepatitis B virus (HBV) infection in HIV-infected [HIV(+)], and HIV-uninfected [HIV(-)] individuals recruited into the same study are limited. HBV infection status and chronic hepatitis B (cHB) were characterized in a multinational clinical trial: HIV Prevention Trials Network (HPTN 052). Method: HBV infection status at enrollment was compared between HIV(+) (N = 1241) and HIV(-) (N = 1232) from 7 HBV-endemic countries. Hepatitis B e antigen and plasma HBV DNA were determined in cHB. Median CD4, median plasma HIV RNA, and prevalence of transaminase elevation were compared in HIV(+) with and without cHB. Significance was assessed with χ, Fisher exact, and median tests. Results: Among all participants, 33.6% had HBV exposure without cHB (8.9% isolated HBV core antibody, "HBcAb"; 24.7% HBcAb and anti-HB surface antibody positive, "recovered"), 4.3% had cHB, 8.9% were vaccinated, and 53.5% were uninfected. Data were similar among HIV(+) and HIV(-) except for isolated HBcAb, which was more prevalent in HIV(+) than HIV(-) [10.1% vs. 7.7%, P = 0.046]. Median HBV DNA trended higher in HIV(+) than in HIV(-). In HIV(+) with cHB versus those without cHB, transaminase elevations were more prevalent (alanine aminotransferase ≤ grade 2, 12% vs. 5.2%, P = 0.037; aspartate aminotransferase ≤ grade 2, 26% vs. 6.0%, P < 0.001), CD4 trended lower, and HIV RNA was similar. Conclusions: HBV infection status did not differ by HIV infection status. HIV co-infection was associated with isolated HBcAb and a trend of increased HBV DNA. In HIV, cHB was associated with mild transaminase elevations and a trend toward lower CD4. | pt_BR |
| Affilliation | Johns Hopkins Hospital. Department of Pathology. Baltimore, MD, USA. | pt_BR |
| Affilliation | Vaccine and Infectious Disease Division. Fred Hutchinson Cancer Research Center. Seattle, WA, USA. | pt_BR |
| Affilliation | Vaccine and Infectious Disease Division. Fred Hutchinson Cancer Research Center. Seattle, WA, USA. | pt_BR |
| Affilliation | Johns Hopkins University School of Medicine. Department of Pathology. Baltimore, USA. | pt_BR |
| Affilliation | Johns Hopkins Hospital. Department of Pathology. Baltimore, MD, USA. | pt_BR |
| Affilliation | FHI 360. Washington, DC, USA. | pt_BR |
| Affilliation | FHI 360. Durham, NC, USA. | pt_BR |
| Affilliation | Chiang Mai University. Research Institute for Health Sciences. Chaing Mai, Thailand. | pt_BR |
| Affilliation | University of North Carolina at Chapel Hill. Chapel Hill, NC, USA / UNC Project-Malawi. Institute for Global Health and Infectious Diseases. Lilongwe, Malawi. | pt_BR |
| Affilliation | YRGCARE Medical Centre. VHS. Chennai, India. | pt_BR |
| Affilliation | College of Medicine-Johns Hopkins Project. Blantyre, Malawi. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Hospital Geral de Nova Iguaçu. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Research Institute for Health Sciences. Chiang Mai University. Chaing Mai, Thailand. | pt_BR |
| Affilliation | Hospital Nossa Senhora da Conceição. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Botswana Harvard AIDS Institute. Gaborone, Botswana. | pt_BR |
| Affilliation | Kenya Medical Research Institute. Kisumu, Kenya / Center for Disease Control. Kisumu, Kenya. | pt_BR |
| Affilliation | University of the Witwatersrand. Perinatal HIV Research Unit. Soweto HPTN CRS. Soweto, South Africa. | pt_BR |
| Affilliation | University of Witwatersrand. Johannesburg, South Africa. | pt_BR |
| Affilliation | Fred Hutchinson Cancer Research Center. Vaccine and Infectious Disease Division. Seattle, WA, USA. | pt_BR |
| Affilliation | University of North Carolina at Chapel Hill. Department of Medicine. Chapel Hill, NC, USA. | pt_BR |
| Affilliation | Johns Hopkins University School of Medicine. Department of Pathology. Baltimore, MD, USA. | pt_BR |
| Affilliation | Johns Hopkins University School of Medicine. Department of Pathology. Baltimore, MD. USA. | pt_BR |
| Affilliation | Johns Hopkins University School of Medicine. Department of Pathology. Baltimore, MD, USA. | pt_BR |
| Subject | HIV | pt_BR |
| Subject | HBV | pt_BR |
| Subject | HIV/HBV co-infection | pt_BR |
| Subject | Chronic HBV infection | pt_BR |
| Subject | Prevalence of HBV infection | pt_BR |
| DeCS | HIV | pt_BR |
| DeCS | HBV | pt_BR |
| DeCS | Coinfection | pt_BR |
