| Author | Rios, Danyelle Romana Alves | |
| Author | Pinheiro, Melina Barros | |
| Author | Oliveira Junior, Wander Valadares de | |
| Author | Gomes, Karina Braga | |
| Author | Carvalho, Andréa Teixeira de | |
| Author | Martins Filho, Olindo Assis | |
| Author | Silva, Ana Cristina Simões e | |
| Author | Dusse, Luci Maria Sant' Ana | |
| Access date | 2018-03-23T18:32:44Z | |
| Available date | 2018-03-23T18:32:44Z | |
| Document date | 2017 | |
| Citation | RIOS, Danyelle Romana Alves et al. Cytokine Signature in End-Stage Renal Disease Patients on Hemodialysis. Dis Markers, 2017, p. 9678391, 2017. | pt_BR |
| ISSN | 0278-0240 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25480 | |
| Language | eng | pt_BR |
| Publisher | Hindawi Publishing Corporation | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | hemodialise | pt_BR |
| Subject in Portuguese | doenças renais | pt_BR |
| Title | Cytokine Signature in End-Stage Renal Disease Patients on Hemodialysis | pt_BR |
| Type | Article | |
| DOI | 10.1155/2017/9678391 | |
| Abstract | Hemodialysis is a modality of blood filtration in which accumulated toxins and water are removed from the body. This treatment is indicated for patients at the end stage of renal disease. Vascular access complications are responsible for 20–25% of all hospitalizations in dialyzed patients. The occurrence of thrombosis in the vascular access is a serious problem that may severely compromise or even make the hemodialysis impossible, which is vital for the patient. The aim of this study was to investigate inflammatory profile in patients undergoing hemodialysis as well as the association between these alterations and vascular access thrombosis. A total of 195 patients undergoing hemodialysis have been evaluated; of which, 149 patients had not experienced vascular access thrombosis (group I) and 46 patients had previously presented this complication (group II). Plasma levels of cytokines including interleukin (IL-) 2, IL-4, IL-5, IL-10, TNF-α, and IFN-γ were measured by cytometric bead array. Our results showed that patients with previous thrombotic events (group II) had higher levels of the IL-2, IL-4, IL-5, and IFN-γ when compared to those in group I. Furthermore, a different cytokine signature was detected in dialyzed patients according to previous occurrences or not of thrombotic events, suggesting that elevated levels of T-helper 1 and T-helper 2 cytokines might, at least in part, contribute to this complication. | pt_BR |
| Affilliation | Universidade Federal de Sao Joao del-Rei. Divinópolis, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Sao Joao del-Rei. Divinópolis, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Sao Joao del-Rei. Divinópolis, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Analises Toxicologicas e Clinicas. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Pediatria. Laboratorio de Investigação Medica Interdiciplinar. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Analises Toxicologicas e Clinicas. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Hemodialysis | pt_BR |
| Subject | chronic diseasis | pt_BR |
| Embargo date | 2024-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
