| Author | Ferreira, Mônica Lopes | |
| Author | Fernandez, Jorge Hernandez | |
| Author | Azevedo, Inácio de Loiola M. Junqueira de | |
| Author | Le Ho, Paulo | |
| Author | Lima, Carla | |
| Author | Valente, Richard H. | |
| Author | Silva, Ana Maria Moura da | |
| Access date | 2018-03-27T16:06:47Z | |
| Available date | 2018-03-27T16:06:47Z | |
| Document date | 2011 | |
| Citation | FERREIRA, Mônica Lopes; et al. Structural and biological characterization of Nattectin, a new C-type lectin from the venomous fish Thalassophryne nattereri. Biochimie, v. 93, p. 971-980, 2011. | pt_BR |
| ISSN | 0300-9084 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25525 | |
| Language | eng | pt_BR |
| Publisher | Elsevier Masson | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Lectinas Tipo C | pt_BR |
| Subject in Portuguese | Galactose | pt_BR |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Venenos de Peixe | pt_BR |
| Title | Structural and biological characterization of Nattectin, a new C-type lectin from the venomous fish Thalassophryne nattereri | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.biochi.2011.03.001 | |
| Abstract | Lectins are glycan-binding receptors that recognize glycan epitopes on foreign pathogens and in the host systems. They can be involved in functions that include innate immunity, development, immune regulation and homeostasis. Several lectins have been purified and characterized from fish species. In this work, using cation-exchange chromatography, a galactose-specific lectin belonging to the family of C-type lectins was isolated from the venom of the Brazilian venomous fish Thalassophryne nattereri. Nattectin is a basic, non-glycosilated, 15 kDa monomeric protein. It exhibits hemagglutination activity that is independent of Ca(2+). We also demonstrated a lectin activity for Nattectin in the innate immune system, especially in neutrophil mobilization in mice, indicating that marine organisms are source of immunomodulator agents. | pt_BR |
| Affilliation | Instituto Butantan. Laboratório Especial de Toxinologia Aplicada/. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Instituto Butantan. Laboratório de Imunopatologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Norte Fluminense Darcy Ribeiro. Laboratório Nacional de Computação Científica. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Instituto Butantan. Centro de Biotecnologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Instituto Butantan. Laboratório Especial de Toxinologia Aplicada/. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Instituto Butantan. Laboratório de Imunopatologia. São Paulo, SP, Brasil. | pt_BR |
| Subject | Nattectin | pt_BR |
| Subject | C-type lectin | pt_BR |
| Subject | Galactose | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | Fish venom | pt_BR |
| Subject | Thalassophryne nattereri | pt_BR |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 14 Vida na água | |
