| Author | De Tommasi, Anna Sara | |
| Author | Giannelli, Alessio | |
| Author | Caprariis, Donato de | |
| Author | Ramos, Rafael Antonio Nascimento | |
| Author | Di Paola, Giancarlo | |
| Author | Crescenzo, Giuseppe | |
| Author | Dantas-Torres, Filipe | |
| Author | Baneth, Gad | |
| Author | Otranto, Domenico | |
| Access date | 2018-03-28T12:10:09Z | |
| Available date | 2018-03-28T12:10:09Z | |
| Document date | 2014 | |
| Citation | DE TOMMASI, A. S. et al. Failure of imidocarb dipropionate and toltrazuril/emodepside plus clindamycin in treating Hepatozoon canis infection. Veterinary Parasitology, v. 200, n. 3–4, p. 242–245, mar. 2014. | pt_BR |
| ISSN | 1873-2550 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25540 | |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Hepatozoon canis | pt_BR |
| Subject in Portuguese | Dipropionato de imidocarbe | pt_BR |
| Subject in Portuguese | Toltrazuril | pt_BR |
| Subject in Portuguese | Emodepside | pt_BR |
| Subject in Portuguese | Clindamicina | pt_BR |
| Subject in Portuguese | Cães | pt_BR |
| Title | Failure of imidocarb dipropionate and toltrazuril/emodepside plus clindamycin in treating Hepatozoon canis infection | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.vetpar.2013.12.013 | |
| Abstract | Hepatozoonosis caused by Hepatozoon canis (Eucoccidiorida, Hepatozoidae) is among the most widespread vector-borne infections of dogs, primarily transmitted by Rhipicephalus sanguineus sensu lato ticks. Based on the absence of a consensus on the treatment regimes for canine hepatozoonosis, the present study aimed to evaluate the efficacy of imidocarb dipropionate (5-6 mg/kg subcutaneously once a week for 6 weeks), and of toltrazuril/emodepside (Procox(®), 15 mg/kg once a day for 6 days) in association with clindamycin (15 mg/kg once a day for 21 days) in treating naturally infected dogs. At the enrollment time (T0), 32 dogs, cytologically or molecularly positive for H. canis, were assigned to test and control groups. Animals were treated according to the specific therapeutic protocol, and the presence of H. canis gamonts was assessed weekly by cytology and PCR throughout six months (T1-T19). In addition, any abnormality in leucocyte morphology was evaluated and recorded. Results indicate that, in spite of a reduction in the percentage of infected dogs, both treatments did not provide parasitological cure. Accordingly, new treatment protocols or active compounds against H. canis should be investigated. | pt_BR |
| Affilliation | Università degli Studi di Bari. Dipartimento di Medicina Veterinaria. Valenzano, Bari, Italy. | pt_BR |
| Affilliation | Università degli Studi di Bari. Dipartimento di Medicina Veterinaria. Valenzano, Bari, Italy. | pt_BR |
| Affilliation | Università degli Studi di Bari. Dipartimento di Medicina Veterinaria. Valenzano, Bari, Italy. | pt_BR |
| Affilliation | Università degli Studi di Bari. Dipartimento di Medicina Veterinaria. Valenzano, Bari, Italy. | pt_BR |
| Affilliation | Università degli Studi di Bari. Dipartimento di Medicina Veterinaria. Valenzano, Bari, Italy. | pt_BR |
| Affilliation | Università degli Studi di Bari. Dipartimento di Medicina Veterinaria. Valenzano, Bari, Italy. | pt_BR |
| Affilliation | Università degli Studi di Bari. Dipartimento di Medicina Veterinaria. Valenzano, Bari, Italy / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil. | pt_BR |
| Affilliation | Hebrew University. School of Veterinary Medicine. Rehovot, Israel. | pt_BR |
| Affilliation | Università degli Studi di Bari. Dipartimento di Medicina Veterinaria. Valenzano, Bari, Italy. | pt_BR |
| Subject | Hepatozoon canis | pt_BR |
| Subject | Imidocarb dipropionate | pt_BR |
| Subject | Toltrazuril | pt_BR |
| Subject | Emodepside | pt_BR |
| Subject | Clindamycin | pt_BR |
| Subject | Dogs | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Clindamicina / uso terapêutico | pt_BR |
| DeCS | Coccidiose / quimioterapia | pt_BR |
| DeCS | Coccidiose / veterinária | pt_BR |
| DeCS | Coccidiostáticos / uso terapêutico | pt_BR |
| DeCS | Depsipeptides / uso terapêutico | pt_BR |
| DeCS | Doenças do Cão / quimioterapia | pt_BR |
| DeCS | Cães | pt_BR |
| DeCS | Quimioterapia, Combinação / veterinária | pt_BR |
| DeCS | Imidocarb / análogos e derivados | pt_BR |
| DeCS | Imidocarb / uso terapêutico | pt_BR |
| DeCS | Falha no tratamento | pt_BR |
| DeCS | Triazinas / uso terapêutico | pt_BR |
| Embargo date | 2050-01-01 | |
