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https://www.arca.fiocruz.br/handle/icict/25560
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Open access
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2018-08-31
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- INI - Artigos de Periódicos [3467]
- IOC - Artigos de Periódicos [12659]
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HTLV-1-INFECTED THYMIC EPITHELIAL CELLS CONVEY THE VIRUS TO CD4+T LYMPHOCYTES
CD4+ T lymphocytes
Thymic epithelial cells
Cell migration
Neuropilin-1
Chemokines
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo.Rio de Janeiro, RJ, Brasil. / National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Brazil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo.Rio de Janeiro, RJ, Brasil. / National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Brazil
Universidade Estadual de Ciências da Saúde de Alagoas. Maceio, Alagoas. Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo.Rio de Janeiro, RJ, Brasil. / National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Brazil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo.Rio de Janeiro, RJ, Brasil. / National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Brazil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo.Rio de Janeiro, RJ, Brasil. / National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Brazil
Universidade Estadual de Ciências da Saúde de Alagoas. Maceio, Alagoas. Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo.Rio de Janeiro, RJ, Brasil. / National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Brazil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo.Rio de Janeiro, RJ, Brasil. / National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Brazil
Abstract
The human T-lymphotropic virus type-1 (HTLV-1) is the causative agent of adult T cell leukemia/lymphoma (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD4+T cells are the main target of HTLV-1, but other cell types are known to be infected, including immature lymphocytes. Developing T cells undergo differentiation in the thymus, through migration and interaction with the thymic microenvironment, in particular with thymic epithelial cells (TEC) the major component of this three dimensional meshwork of non-lymphoid cells. Herein, we show that TEC express the receptors for HTLV-1 and can be infected by this virus through cell-cell contact and by cell-free virus suspensions. The expression of anti-apoptosis, chemokine and adhesion molecules genes are altered in HTLV-1-infected TEC, although gene expression of antigen presentation molecules remained unchanged. Furthermore, HTLV-1-infected TEC transmitted the virus to a CD4+T cell line and to CD4+T cells from healthy donors, during in vitro cellular co-cultures. Altogether, our data point to the possibility that the human thymic epithelial cells play a role in the establishment and progression of HTLV-1 infection, functioning as a reservoir and transmitting the virus to maturing CD4+T lymphocytes, which in turn will cause disease in the periphery.
Keywords
HTLV-I infectionCD4+ T lymphocytes
Thymic epithelial cells
Cell migration
Neuropilin-1
Chemokines
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