Author | Moraes, Joyce L | |
Author | Moraes, Amanda B | |
Author | Aran, Veronica | |
Author | Alves, Marcelo R | |
Author | Schluckbier, Luciene | |
Author | Duarte, Mariana | |
Author | Toscano, Edson | |
Author | Zamboni, Mauro | |
Author | Sternberg, Cinthya | |
Author | de Moraes, Emanuela | |
Author | Lapa E Silva, José R | |
Author | Ferreira, Carlos Gil | |
Access date | 2018-04-03T19:10:10Z | |
Available date | 2018-04-03T19:10:10Z | |
Document date | 2017 | |
Citation | MORAES, Joyce L. et al. Functional analysis of polymorphisms in the COX‑2 gene and risk of lung cancer. Molecular and Clinical Oncology, v. 6, p. 494-205, 2017. | pt_BR |
ISSN | 2049-9450 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/25602 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Title | Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer | pt_BR |
Type | Article | pt_BR |
DOI | 10.3892/mco.2017.1167 | |
Abstract | The enzyme cyclooxygenase 2 (COX-2) is known to be involved in tumorigenesis and metastasis in certain types of cancer. Nevertheless, the prognostic value of COX-2 overexpression and its polymorphisms in patients with non-small cell lung cancer (NSCLC) have yet to be fully elucidated. The aim of the present study was to investigate the association between the three most commonly studied COX-2 gene polymorphisms (-1195 G/A, -765 G/C and 8473 T/C) with COX-2 expression and lung cancer risk in a Brazilian cohort. In the present hospital based, case-control retrospective study, 104 patients with NSCLC and 202 cancer free control subjects were genotyped for -1195 G/A, -765 G/C and 8473 T/C polymorphisms using allelic discrimination with a reverse transcription quantitative polymerase chain reaction method. COX-2 mRNA expression was analyzed in surgically resected tumors from 34 patients with NSCLC. The results revealed that COX-2 expression levels were higher in tumor tissue compared with normal lung tissue. However, this overexpression of COX-2 was not associated with the patient outcome, and furthermore, none of the analyzed polymorphisms were associated with the risk of developing lung cancer, COX-2 overexpression, or the overall survival of the patients with NSCLC. Taken together, the findings described in the present study do not support a major role for COX-2 polymorphisms and COX-2 overexpression in lung carcinogenesis within the Brazilian population. | pt_BR |
Affilliation | Instituto Nacional de Câncer José Alencar Gomes da Silva, Divisão de Pesquisa Clínica, Rio de Janeiro, Rj, Brasil | pt_BR |
Affilliation | Instituto Nacional de Câncer José Alencar Gomes da Silva, Divisão de Pesquisa Clínica, Rio de Janeiro, Rj, Brasil | pt_BR |
Affilliation | Instituto Nacional de Câncer José Alencar Gomes da Silva, Divisão de Pesquisa Clínica, Rio de Janeiro, Rj, Brasil | pt_BR |
Affilliation | Fundação Oswaldo cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Instituto Nacional de Câncer José Alencar Gomes da Silva, Divisão de Pesquisa Clínica, Rio de Janeiro, Rj, Brasil | pt_BR |
Affilliation | Instituto Nacional de Câncer José Alencar Gomes da Silva, Divisão de Pesquisa Clínica, Rio de Janeiro, Rj, Brasil | pt_BR |
Affilliation | Instituto Nacional de Câncer José Alencar Gomes da Silva, Departamento de Cirurgia Torácica, Rio de Janeiro, Rj, Brasil | pt_BR |
Affilliation | Instituto Nacional de Câncer José Alencar Gomes da Silva, Departamento de Cirurgia Torácica, Rio de Janeiro, Rj, Brasil | pt_BR |
Affilliation | Instituto Nacional de Câncer José Alencar Gomes da Silva, Divisão de Pesquisa Clínica, Rio de Janeiro, Rj, Brasil | pt_BR |
Affilliation | Instituto Nacional de Câncer José Alencar Gomes da Silva, Divisão de Pesquisa Clínica, Rio de Janeiro, Rj, Brasil | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Instituto de Medicina Torácica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | National Clinical Cancer Research Network (RNPCC) SCTIE/MS. / Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, Brazil | pt_BR |
Subject | Cyclooxygenase 2 | pt_BR |
Subject | Tumorigenesis | pt_BR |
Subject | Polymorphism | pt_BR |
Subject | Lung cancer | pt_BR |
Subject | Cohort | pt_BR |
Embargo date | 2018-12-31 | |