Author | Nagib, Patrícia R. A. | |
Author | Gameiro, Jacy | |
Author | Silva, Luiz Guilherme Stivanin | |
Author | Arruda, Maria Sueli Parreira de | |
Author | Verde, Déa Maria Serra Villa | |
Author | Savino, Wilson | |
Author | Verinaud, Liana | |
Access date | 2018-04-12T15:07:15Z | |
Available date | 2018-04-12T15:07:15Z | |
Document date | 2010 | |
Citation | NAGIB, Patrícia R. A. et al. Thymic microenvironmental alterations in experimentally induced diabetes. Immunobiology, v.215, p.971-979, 2010 | pt_BR |
ISSN | 0171-2985 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/25813 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Timo | pt_BR |
Subject in Portuguese | Diabetes | pt_BR |
Subject in Portuguese | Matriz extracelular | pt_BR |
Subject in Portuguese | Quimiocinas | pt_BR |
Subject in Portuguese | Microambiente timo | pt_BR |
Title | Thymic microenvironmental alterations in experimentally induced diabetes | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.imbio.2010.02.001 | |
Abstract | Little is known about the immunologic consequences from endocrine changes observed in diabetes. Since a preserved thymic microenvironment is of critical importance for the T cell development and maturation, we have examined the thymus from alloxan-diabetic mice. An intense thymic atrophy accompanied by changes in histological pattern and in thymocyte subpopulations were observed in diabetic mice. Laminin and fibronectin, which are closely associated with thymocytes maturation, were evaluated, but, only laminin presented an altered distribution and density in thymuses from diabetes group. the expression of fibronectin and laminin receptors was found to be decreased in diabetic mice. There was also intense decrease in the expression of two important chemokines for thymus, CCL25 and CXCL12, and in the CCR9 (CCL25 receptor), but the expression of CXCR4 (CXCL12 receptor) did not drop on cells. However, no significant difference was observed in the in vitro thymocytes migratory capacity from diabetic mice. The results show significant alterations in thymus microenvironment in diabetes and offer insights for studies involving endocrine influences on lymphatic organs and T cell maturation. | pt_BR |
Affilliation | Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Anatomia, Biologia Celular e Fisiologia. Campinas, SP, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Anatomia, Biologia Celular e Fisiologia. Campinas, SP, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Anatomia, Biologia Celular e Fisiologia. Campinas, SP, Brasil. | pt_BR |
Affilliation | Universidade Estadual Julio de Mesquita Filho. Faculdade de Ciências. Departamento de Ciências Biológicas. Bauru, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Anatomia, Biologia Celular e Fisiologia. Campinas, SP, Brasil. | pt_BR |
Subject | Thymus | pt_BR |
Subject | Thymic microenvironment | pt_BR |
Subject | Diabetes | pt_BR |
Subject | Extracellular matrix | pt_BR |
Subject | Chemokines | pt_BR |
e-ISSN | 1878-3279 | |
Embargo date | 2030-01-01 | |