| Author | Savino, Wilson | |
| Author | Dardenne, Mireille | |
| Access date | 2018-04-12T16:06:18Z | |
| Available date | 2018-04-12T16:06:18Z | |
| Document date | 2010 | |
| Citation | SAVINO, Wilson; DARDENNE, Mireille. Nutritional imbalances and infections affect the thymus: consequences on T-cell-mediated immune responses. Proceedings of the Nutrition Society, v.69, n.4, p.636–643, 2010. | pt_BR |
| ISSN | 0029-6651 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25820 | |
| Description | The 3rd International Immunonutrition Workshop was held at Platja D’Aro, Girona, Spain on 21–24 October 2009 Session 2: Micronutrients and the immune system | pt_BR |
| Language | eng | pt_BR |
| Publisher | Cambridge University Press | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Desequilíbrios nutricionais | pt_BR |
| Subject in Portuguese | Infecções | pt_BR |
| Subject in Portuguese | Timo | pt_BR |
| Subject in Portuguese | Respostas imunes | pt_BR |
| Subject in Portuguese | células T | pt_BR |
| Title | Nutritional imbalances and infections affect the thymus: consequences on T-cell-mediated immune responses | pt_BR |
| Type | Article | |
| DOI | 10.1017/S0029665110002545 | |
| Abstract | The thymus gland, where T lymphocyte development occurs, is targeted in malnutrition secondary to protein energy deficiency. There is a severe thymic atrophy, resulting from massive thymocyte apoptosis (particularly affecting the immature CD4+CD8+ cell subset) and decrease in cell proliferation. The thymic microenvironment (the non-lymphoid compartment that drives intrathymic T-cell development) is also affected in malnutrition: morphological changes in thymic epithelial cells were found, together with a decrease of thymic hormone production, as well as an increase of intrathymic contents of extracellular proteins. Profound changes in the thymus can also be seen in deficiencies of vitamins and trace elements. Taking Zn deficiency as an example, there is a substantial thymic atrophy. Importantly, marginal Zn deficiency in AIDS subjects, children with diarrhoea and elderly persons, significantly impairs the host's immunity, resulting in an increased risk of opportunistic infections and mortality; effects that are reversed by Zn supplementation. Thymic changes also occur in acute infectious diseases, including a severe thymic atrophy, mainly due to the depletion of CD4+CD8+ thymocytes, decrease in thymocyte proliferation, in parallel to densification of the epithelial network and increase in the extracellular matrix contents, with consequent disturbances in thymocyte migration and export. In conclusion, the thymus is targeted in several conditions of malnutrition as well as in acute infections. These changes are related to the impaired peripheral immune response seen in malnourished and infected individuals. Thus, strategies inducing thymus replenishment should be considered as adjuvant therapeutics to improve immunity in malnutrition and/or acute infectious diseases. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Université Paris Descartes. Hôpital Necker. Paris, France. | pt_BR |
| Subject | Thymus | pt_BR |
| Subject | immune responses | pt_BR |
| Subject | Nutritional imbalances | pt_BR |
| Subject | infectious | pt_BR |
| Subject | T-cell | pt_BR |
| e-ISSN | 1475-2719 | |
| xmlui.metadata.dc.subject.ods | 02 Fome zero e agricultura sustentável | |
