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AutorSmaniotto, Salete
AutorCruz, Daniella Arêas Mendes da
AutorPinto, Carla Eponina Carvalho
AutorAraujo, Luiza M.
AutorDardenne, Mireille
AutorSavino, Wilson
Data de acesso2018-04-12T17:24:53Z
Data de disponibilização2018-04-12T17:24:53Z
Data do publicação2010
CitaçãoSMANIOTTO, Salete; et al. Combined role of extracellular matrix and chemokines on peripheral lymphocyte migration in growth hormone transgenic mice. Brain, Behavior, and Immunity. v.24, p.451–461, Dec. 2010.pt_BR
ISSN0889-1591pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/25828
Idiomaengpt_BR
EditorElsevierpt_BR
Direito Autoralrestricted access
TítuloCombined role of extracellular matrix and chemokines on peripheral lymphocyte migration in growth hormone transgenic micept_BR
Tipo do documentoArticle
DOI10.1016/j.bbi.2009.11.014
Resumo em InglêsPrevious evidence indicated that growth hormone (GH) modulates cell migration in the thymus, and that extracellular matrix and chemokines are involved. Herein, we studied migration of peripheral lymphocytes derived from spleen and lymph nodes of GH-transgenic (GH-Tg) mice. We initially found that the relative cell numbers (normalized per gram of body weight) in lymph nodes and spleens from GH-Tg were higher at all ages tested (2-3, 7 and 12 months), as compared to wild type age-matched controls. Functionally, we found that lymphocyte migration triggered by laminin or fibronectin was enhanced in cells from GH-Tg versus control mice, independent of the organ from which the cells were derived (as ascertained in young adult animals). However, such an enhancement in migration was statistically significant only for CD4+ and CD8+ T cells from mesenteric lymph nodes. Migration of lymphocytes from mesenteric lymph nodes of GH-Tg mice, triggered by the chemokine CXCL12, in conjunction with laminin or fibronectin, was enhanced compared to lymphocytes from control mice. Rather surprisingly, the membrane levels of the corresponding extracellular matrix or chemokine receptors in peripheral lymphoid organs of GH-Tg mice did not necessarily correlate with the changes seen in migratory responses. In conclusion, our data show for the first time that GH alters lymphocyte migration in the periphery of the immune system. Considering that GH is used as an adjuvant therapeutic agent in immunodeficiencies, including AIDS, the concepts defined herein provide relevant background knowledge for future GH-related immune interventions.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Université Paris Descartes. Hôpital Necker. Paris, France / Universidade Federal de Alagoas. Instituto de Ciências Biológicas e da Saúde. Laboratório de Imunohistologia. Maceió, AL, Brasilpt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Université Paris Descartes. Hôpital Necker. Paris, France.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil / Universidade Federal Fluminense. Instituto de Biologia. Departamento de Imunologia. Niterói, RJ, Brasil.pt_BR
AfiliaçãoUniversité Paris Descartes. Hôpital Necker. Paris, France.pt_BR
AfiliaçãoUniversité Paris Descartes. Hôpital Necker. Paris, France.pt_BR
AfiliaçãoFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ. Brasil.pt_BR
Palavras-chave em inglêsLymph nodespt_BR
Palavras-chave em inglêsSpleenpt_BR
Palavras-chave em inglêsExtracellular matrixpt_BR
Palavras-chave em inglêsIntegrinspt_BR
Palavras-chave em inglêsChemokinespt_BR
DeCSQuimiocinapt_BR
DeCSMatriz Extracelularpt_BR
DeCSIntegrinaspt_BR
DeCSBaçopt_BR
DeCSLinfonodospt_BR
e-ISSN1090-2139
Data de embargo2030-01-01


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