| Author | Brahimi, Karina | |
| Author | Martins, Yuri Chaves | |
| Author | Zanini, Graziela Maria | |
| Author | Cruz, Maria de Fátima Ferreira da | |
| Author | Daniel-Ribeiro, Cláudio Tadeu | |
| Access date | 2018-04-17T15:19:38Z | |
| Available date | 2018-04-17T15:19:38Z | |
| Document date | 2011 | |
| Citation | BRAHIMI, Karima et al. Monoclonal auto-antibodies and sera of autoimmune patients react with Plasmodium falciparum and inhibit its in vitro growth. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 106, Suppl. I, p. 44-51, 2011. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25903 | |
| Description | Graziela Maria Zanini. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Plasmodium falciparum | pt_BR |
| Subject in Portuguese | Malária | pt_BR |
| Subject in Portuguese | Autoimunidade | pt_BR |
| Subject in Portuguese | Doenças Autoimunes | pt_BR |
| Subject in Portuguese | Autoanticorpos | pt_BR |
| Subject in Portuguese | Proteção imunológica | pt_BR |
| Title | Monoclonal auto-antibodies and sera of autoimmune patients react with Plasmodium falciparum and inhibit its in vitro growth | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/s0074-02762011000900006 | pt_BR |
| Abstract | The relationship between autoimmunity and malaria is not well understood. To determine whether autoimmune responses have a protective role during malaria, we studied the pattern of reactivity to plasmodial antigens of sera from 93 patients with 14 different autoimmune diseases (AID) who were not previously exposed to malaria. Sera from patients with 13 different AID reacted against Plasmodium falciparum by indirect fluorescent antibody test with frequencies varying from 33-100%. In addition, sera from 37 AID patients were tested for reactivity against Plasmodium yoelii 17XNL and the asexual blood stage forms of three different P. falciparum strains. In general, the frequency of reactive sera was higher against young trophozoites than schizonts (p < 0.05 for 2 strains), indicating that the antigenic determinants targeted by the tested AID sera might be more highly expressed by the former stage. The ability of monoclonal auto-antibodies (auto-Ab) to inhibit P. falciparum growth in vitro was also tested. Thirteen of the 18 monoclonal auto-Ab tested (72%), but none of the control monoclonal antibodies, inhibited parasite growth, in some cases by greater than 40%. We conclude that autoimmune responses mediated by auto-Ab may present anti-plasmodial activity. | pt_BR |
| Affilliation | Institut Pasteur. Laboratorie de Parasitologie Biomédicale. Paris, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Auto-antibodies | pt_BR |
| Subject | Autoimmune diseases | pt_BR |
| Subject | Autoimmunity | pt_BR |
| Subject | Immune protection | pt_BR |
| Subject | Malaria | pt_BR |
| Subject | Plasmodium falciparum | pt_BR |
| e-ISSN | 1678-8060 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
