| Author | Mekhaiel, David N. A. | |
| Author | Daniel-Ribeiro, Cláudio Tadeu | |
| Author | Cooper, Philip J. | |
| Author | Pleass, Richard J. | |
| Access date | 2018-04-17T16:13:58Z | |
| Available date | 2018-04-17T16:13:58Z | |
| Document date | 2011 | |
| Citation | MEKHAIEL, David N. A. et al. Do regulatory antibodies offer an alternative mechanism to explain the hygiene hypothesis?. Trends in Parasitology, v.27, n.12, p.523-529, 2011. | pt_BR |
| ISSN | 1471-4922 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25907 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Parasitos | pt_BR |
| Subject in Portuguese | Anticorpos | pt_BR |
| Subject in Portuguese | hipótese de higiene | pt_BR |
| Title | Do regulatory antibodies offer an alternative mechanism to explain the hygiene hypothesis? | pt_BR |
| Type | Article | |
| Abstract | The ‘hygiene hypothesis’, or lack of microbial and parasite
exposure during early life, is postulated as an explanation
for the recent increase in autoimmune and allergic diseases
in developed countries. The favored mechanism is
that microbial and parasite-derived products interact directly
with pathogen recognition receptors to subvert
proinflammatory signaling via T regulatory cells, thereby
inducing anti-inflammatory effects and control of autoimmune
disease. Parasites, such as helminths, are considered
to have a major role in the induction of immune
regulatory mechanisms among children living in developing
countries. Invoking Occam’s razor, we believe we
can select an alternative mechanism to explain the hygiene
hypothesis, based on antibody-mediated inhibition
of immune responses that may more simply explain the
available evidence. | pt_BR |
| Affilliation | Liverpool School of Tropical Medicine. Liverpool, UK. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa em Malária e Treinamento. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Liverpool School of Tropical Medicine. Liverpool, UK. | pt_BR |
| Affilliation | Liverpool School of Tropical Medicine. Liverpool, UK. | pt_BR |
| Subject | hygiene hypothesis | pt_BR |
| Subject | antibodies | pt_BR |
| Subject | Parasites | pt_BR |
| e-ISSN | 1471-5007 | |
