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AuthorFigueiró, Henrique Vieira
AuthorLi, Gang
AuthorTrindade, Fernanda J.
AuthorGeraldo, Juliana Assis
AuthorPais, Fabiano Sviatopolk Mirsky
AuthorFernandes, Gabriel da Rocha
AuthorSantos, Sarah H. D.
AuthorHughes, Graham M.
AuthorKomissarov, Aleksey
AuthorAntunes, Agostinho
AuthorTrinca, Cristine S.
AuthorRodrigues, Maíra R.
AuthorLinderoth, Tyler
AuthorBi, Ke
AuthorSilveira, Leandro
AuthorAzevedo, Fernando C. C.
AuthorKantek, Daniel
AuthorRamalho, Emiliano
AuthorBrassaloti, Ricardo A.
AuthorVillela, Priscilla M. S.
AuthorNunes, Adauto L. V.
AuthorTeixeira, Rodrigo H. F.
AuthorMorato, Ronaldo G.
AuthorLoska, Damian
AuthorSaragüeta, Patricia
AuthorGabaldón, Toni
AuthorTeeling, Emma C.
AuthorO’Brien, Stephen J.
AuthorNielsen, Rasmus
AuthorCoutinho, Luiz L.
AuthorOliveira, Guilherme Corrêa de
AuthorMurphy, William J.
AuthorEizirik, Eduardo
Access date2018-04-18T12:48:24Z
Available date2018-04-18T12:48:24Z
Document date2017
CitationFIGUEIRÓ, Henrique Vieira et al. Genome-wide signatures of complex introgression and adaptive evolution in the big cats. Sci Adv., v. 3, n. 7, e1700299, 2017.pt_BR
ISSN2375-2548pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/25924
Languageengpt_BR
PublisherAmerican Association for the Advancement of Sciencept_BR
Rightsrestricted accesspt_BR
Subject in Portuguesegatospt_BR
TitleGenome-wide signatures of complex introgression and adaptive evolution in the big catspt_BR
TypeArticle
DOI10.1126/sciadv.1700299
AbstractThe great cats of the genus Panthera comprise a recent radiation whose evolutionary history is poorly understood. Their rapid diversification poses challenges to resolving their phylogeny while offering opportunities to investigate the historical dynamics of adaptive divergence. We report the sequence, de novo assembly, and annotation of the jaguar (Panthera onca) genome, a novel genome sequence for the leopard (Panthera pardus), and comparative analyses encompassing all living Panthera species. Demographic reconstructions indicated that all of these species have experienced variable episodes of population decline during the Pleistocene, ultimately leading to small effective sizes in present-day genomes. We observed pervasive genealogical discordance across Panthera genomes, caused by both incomplete lineage sorting and complex patterns of historical interspecific hybridization. We identified multiple signatures of species-specific positive selection, affecting genes involved in craniofacial and limb development, protein metabolism, hypoxia, reproduction, pigmentation, and sensory perception. There was remarkable concordance in pathways enriched in genomic segments implicated in interspecies introgression and in positive selection, suggesting that these processes were connected. We tested this hypothesis by developing exome capture probes targeting ~19,000 Panthera genes and applying them to 30 wild-caught jaguars. We found at least two genes (DOCK3 and COL4A5, both related to optic nerve development) bearing significant signatures of interspecies introgression and within-species positive selection. These findings indicate that post-speciation admixture has contributed genetic material that facilitated the adaptive evolution of big cat lineages.pt_BR
AffilliationFaculdade de Biociências. Laboratório de Biologia Genômica e Molecular. Pontificia Universidade Catolica do Rio Grande do Sul. Porto Alegre, RS, Brazil.pt_BR
AffilliationDepartment of Veterinary Integrative Biosciences. Texas A&M University. College Station, TX, USA.pt_BR
AffilliationFaculdade de Biociências. Laboratório de Biologia Genômica e Molecular. Pontificia Universidade Catolica do Rio Grande do Sul. Porto Alegre, RS, Brazil.pt_BR
AffilliationFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.pt_BR
AffilliationFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.pt_BR
AffilliationFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.pt_BR
AffilliationFaculdade de Biociências. Laboratório de Biologia Genômica e Molecular. Pontificia Universidade Catolica do Rio Grande do Sul. Porto Alegre, RS, Brazil.pt_BR
AffilliationSchool of Biology and Environmental Science. University College Dublin. Dublin, Ireland.pt_BR
AffilliationTheodosius Dobzhansky Center for Genome Bioinformatics. Saint Petersburg State University. St. Petersburg, Russia.pt_BR
AffilliationUniversidade do Porto. Faculdade de Ciências and CIIMAR/CIMAR. Departamento de Biologia. Porto, Portugal.pt_BR
AffilliationFaculdade de Biociências. Laboratório de Biologia Genômica e Molecular. Pontificia Universidade Catolica do Rio Grande do Sul. Porto Alegre, RS, Brazil.pt_BR
AffilliationFaculdade de Biociências. Laboratório de Biologia Genômica e Molecular. Pontificia Universidade Catolica do Rio Grande do Sul. Porto Alegre, RS, Brazil.pt_BR
AffilliationDepartment of Integrative Biology. University of California. Berkeley, Berkeley, CA, USA.pt_BR
AffilliationComputational Genomics Resource Laboratory. California Institute for Quantitative Biosciences and Museum of Vertebrate Zoology. University of California. Berkeley, Berkeley, CA, USA.pt_BR
AffilliationInstituto Onça Pintada. Mineiros, GO, Brazil.pt_BR
AffilliationUniversidade Federal de São João Del Rey, São João Del Rey, Minas Gerais, Brazil/Instituto Pró-Carnívoros. Atibaia, SP, Brazil.pt_BR
AffilliationFaculdade de Biociências. Laboratório de Biologia Genômica e Molecular. Pontificia Universidade Catolica do Rio Grande do Sul. Porto Alegre, RS, Brazil/ Instituto Chico Mendes de Conservação da Biodiversidade. Brasília, DF, Brazilpt_BR
AffilliationInstituto Pró-Carnívoros. Atibaia, SP, Brazil/Instituto de Desenvolvimento Sustentável Mamirauá. Tefé, AM, Brazil.pt_BR
AffilliationEscola Superior de Agricultura Luiz de Queiroz. Piracicaba, São Paulo, Brazil.pt_BR
AffilliationEscola Superior de Agricultura Luiz de Queiroz. Piracicaba, São Paulo, Brazil.pt_BR
AffilliationEscola Superior de Agricultura Luiz de Queiroz. Piracicaba, São Paulo, Brazil.pt_BR
AffilliationZoológico Municipal de Sorocaba. Sorocaba, SP, Brazil.pt_BR
AffilliationZoológico Municipal de Sorocaba. Sorocaba, SP, Brazil/Universidade Estadual Paulista. Programa de Pós-Graduação em Animais Selvagens. Botucatu, SP, Brazil.pt_BR
AffilliationInstituto Pró-Carnívoros. Atibaia, SP, Brazil/Instituto Chico Mendes de Conservação da Biodiversidade. Brasília, DF, Brazilpt_BR
AffilliationCentre for Genomic Regulation. Bioinformatics and Genomics Programme. Barcelona, Spain/Universitat Pompeu Fabra. Barcelona, Spainpt_BR
AffilliationInstituto de Biología y Medicina Experimental. Buenos Aires, Argentina.pt_BR
AffilliationCentre for Genomic Regulation. Bioinformatics and Genomics Programme. Barcelona, Spain/Universitat Pompeu Fabra. Barcelona, Spain/Institució Catalana de Recerca i Estudis Avançats. Barcelona, Spain.pt_BR
AffilliationSchool of Biology and Environmental Science. University College Dublin. Dublin, Ireland.pt_BR
AffilliationTheodosius Dobzhansky Center for Genome Bioinformatics. Saint Petersburg State University. St. Petersburg, Russia.pt_BR
AffilliationDepartment of Integrative Biology. University of California. Berkeley, Berkeley, CA, USA.pt_BR
AffilliationEscola Superior de Agricultura Luiz de Queiroz. Piracicaba, São Paulo, Brazil.pt_BR
AffilliationFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/Instituto Tecnológico Vale. Belém, Pará, Brazil.pt_BR
AffilliationDepartment of Veterinary Integrative Biosciences. Texas A&M University. College Station, TX, USA.pt_BR
AffilliationFaculdade de Biociências. Laboratório de Biologia Genômica e Molecular. Pontificia Universidade Catolica do Rio Grande do Sul. Porto Alegre, RS, Brazil/ Instituto Pró-Carnívoros. Atibaia, SP, Brazil.pt_BR
Subjectcatspt_BR
Embargo date2022-01-01


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