Author | Melo, Andréa Barbosa de | |
Author | Silva, Maria da Paz C. da | |
Author | Magalhães, Maria Cecília F. | |
Author | Gil, Laura Helena Vega Gonzales | |
Author | Carvalho, Eduardo M. Freese de | |
Author | Braga-Neto, Ulisses M. | |
Author | Bertani, Giovani Rota | |
Author | Marques, Ernesto T. A. | |
Author | Cordeiro, Marli Tenório | |
Access date | 2018-04-20T12:17:59Z | |
Available date | 2018-04-20T12:17:59Z | |
Document date | 2011 | |
Citation | DE MELO, A. B. et al. Description of a prospective 17DD yellow fever vaccine cohort in Recife, Brazil. The American Journal of Tropical Medicine and Hygiene, v. 85, n. 4, p. 739–747, out. 2011. | pt_BR |
ISSN | 1476-1645 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/25973 | |
Sponsorship | Os autores gostariam de agradecer o apoio do Instituto Nacional de Alergia e Doenças Infecciosas (NIAID / NIH) do Subsídio N01-AI-40085, do Subsídio da Fundação Oswaldo Cruz PDTIS-RVR9, do Prêmio Nacional de Fundação Científica CCF-0845407 e do Conselho Nacional de Pesquisa (CAPES; bolsa de doutorado para Andréa Melo). | pt_BR |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Vírus da febre amarela | pt_BR |
Subject in Portuguese | Vaccine | pt_BR |
Subject in Portuguese | Resposta imune | pt_BR |
Title | Description of a prospective 17DD yellow fever vaccine cohort in Recife, Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.4269/ajtmh.2011.10-0496 | |
Abstract | From September 2005 to March 2007, 238 individuals being vaccinated for the first time with the yellow fever (YF) -17DD vaccine were enrolled in a cohort established in Recife, Brazil. A prospective study indicated that, after immunization, anti-YF immunoglobulin M (IgM) and anti-YF IgG were present in 70.6% (IgM) and 98.3% (IgG) of the vaccinated subjects. All vaccinees developed protective immunity, which was detected by the plaque reduction neutralization test (PRNT) with a geometric mean titer of 892. Of the 238 individuals, 86.6% had IgG antibodies to dengue virus; however, the presence of anti-dengue IgG did not interfere significantly with the development of anti-YF neutralizing antibodies. In a separate retrospective study of individuals immunized with the 17DD vaccine, the PRNT values at 5 and 10 years post-vaccination remained positive but showed a significant decrease in neutralization titer (25% with PRNT titers < 100 after 5 years and 35% after 10 years). | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Pernambuco. Departamento de Bioquímica. Recife, PE, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Saúde Coletiva. Recife, PE, Brasil. | pt_BR |
Affilliation | Texas A&M University. College Station. Department of Electrical Engineering.Texa, USA. | pt_BR |
Affilliation | Universidade Federal de Pernambuco. Departamento de Bioquímica. Recife, PE, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil / Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Recife, PE, Brasil / Secretaria de Saúde do Estado de Pernambuco. Central Laboratory of Public Health. Recife, PE, Brazil. | pt_BR |
Subject | Yellow fever virus | pt_BR |
Subject | Vacina | pt_BR |
Subject | Immune response | pt_BR |
DeCS | Anticorpos virais / sangue | pt_BR |
DeCS | Brasil | pt_BR |
DeCS | Ensaio de Imunoadsorção Enzimática | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Testes de Neutralização | pt_BR |
DeCS | Estudos Prospectivos | pt_BR |
DeCS | Ensaio de Placa Viral | pt_BR |
DeCS | Vacina Contra Febre Amarela / administração & dosagem | pt_BR |
DeCS | Vacina contra Febre Amarela / imunologia | pt_BR |