| Author | Cartaxo, Marina F. S. | |
| Author | Ayres, Constância F. J. | |
| Author | Weetman, David | |
| Access date | 2018-04-20T13:23:57Z | |
| Available date | 2018-04-20T13:23:57Z | |
| Document date | 2011 | |
| Citation | CARTAXO, M. F. S.; AYRES, C. F. J.; WEETMAN, D. Loss of genetic diversity in Culex quinquefasciatus targeted by a lymphatic filariasis vector control program in Recife, Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 105, n. 9, p. 491–499, set. 2011. | pt_BR |
| ISSN | 1878-3503 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25977 | |
| Sponsorship | Este projeto foi financiado pela Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE) APQ0060-2.02 / 07. | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Culex quinquefasciatus | pt_BR |
| Subject in Portuguese | Bacillus sphaericus | pt_BR |
| Subject in Portuguese | Filariose linfática | pt_BR |
| Subject in Portuguese | Microssatélites | pt_BR |
| Subject in Portuguese | Desvio genético | pt_BR |
| Subject in Portuguese | Gene receptor cqm1 | pt_BR |
| Title | Loss of genetic diversity in Culex quinquefasciatus targeted by a lymphatic filariasis vector control program in Recife, Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.trstmh.2011.05.004 | |
| Abstract | Recife is one of the largest cities in north-eastern Brazil and is endemic for lymphatic filariasis transmitted by Culex quinquefasciatus. Since 2003 a control program has targeted mosquito larvae by elimination of breeding sites and bimonthly application of Bacillus sphaericus. To assess the impact of this program on the local vector population we monitored the genetic diversity and differentiation of Cx. quinquefasciatus using microsatellites and a B. sphaericus-resistance associated mutation (cqm1(REC)) over a 3-year period. We detected a significant but gradual decline in allelic diversity, which, coupled with subtle temporal genetic structure, suggests a major impact of the control program on the vector population. Selection on cqm1(REC) does not appear to be involved with loss of neutral diversity from the population, with no temporal trend in resistant allele frequency and no correlation with microsatellite differentiation. The evidence for short-term genetic drift we detected suggests a low ratio of effective population size: census population size for Cx. quinquefasciatus, perhaps coupled with strong geographically-restricted population structure. Spatial definition of populations will be an important step for success of an expanded vector control program. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Entomologia. Recife, PE, Brasil. | pt_BR |
| Affilliation | Liverpool School of Tropical Medicine. Vector Group. Liverpool, UK. | pt_BR |
| Subject | Culex quinquefasciatus | pt_BR |
| Subject | Bacillus sphaericus | pt_BR |
| Subject | Lymphatic filariasis | pt_BR |
| Subject | Microsatellite | pt_BR |
| Subject | Genetic drift | pt_BR |
| Subject | Receptor gene cqm1 | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Brasil / epidemiologia | pt_BR |
| DeCS | Culex / genética | pt_BR |
| DeCS | Filariose Linfática / epidemiologia | pt_BR |
| DeCS | Elefantíase, filarial / prevenção & controle | pt_BR |
| DeCS | Freqüência Genética | pt_BR |
| DeCS | Deriva Genética | pt_BR |
| DeCS | Variação genética | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Repetições de Microssatélites | pt_BR |
| DeCS | Controle de Mosquito | pt_BR |
| DeCS | Mutação | pt_BR |
| DeCS | Densidade populacional | pt_BR |
| Embargo date | 2050-01-01 | |
