| Author | Figueiredo, Maria Marta | |
| Author | Costa, Pedro Augusto Carvalho | |
| Author | Diniz, Suelen Queiroz | |
| Author | Henriques, Priscilla Miranda | |
| Author | Kano, Flora Satiko | |
| Author | Tada, Mauro Sugiro | |
| Author | Pereira, Dhelio Batista | |
| Author | Soares, Irene Silva | |
| Author | Martins Filho, Olindo Assis | |
| Author | Jankovic, Dragana | |
| Author | Gazzinelli, Ricardo Tostes | |
| Author | Antonelli, Lis Ribeiro do Valle | |
| Access date | 2018-04-20T17:46:00Z | |
| Available date | 2018-04-20T17:46:00Z | |
| Document date | 2017 | |
| Citation | FIGUEIREDO, Maria Marta et al. T follicular helper cells regulate the activation of B lymphocytes and antibody production during Plasmodium vivax infection. PLoS Pathog. 2017 Jul 10;13(7):e1006484. | pt_BR |
| ISSN | 1553-7366 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25990 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Malaria | pt_BR |
| Subject in Portuguese | B celulas | pt_BR |
| Subject in Portuguese | Plasmodium | pt_BR |
| Title | T follicular helper cells regulate the activation of B lymphocytes and antibody production during Plasmodium vivax infection | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.ppat.1006484 | |
| Abstract | Although the importance of humoral immunity to malaria has been established, factors that control antibody production are poorly understood. Follicular helper T cells (Tfh cells) are pivotal for generating high-affinity, long-lived antibody responses. While it has been proposed that expansion of antigen-specific Tfh cells, interleukin (IL) 21 production and robust germinal center formation are associated with protection against malaria in mice, whether Tfh cells are found during Plasmodium vivax (P. vivax) infection and if they play a role during disease remains unknown. Our goal was to define the role of Tfh cells during P. vivax malaria. We demonstrate that P. vivax infection triggers IL-21 production and an increase in Tfh cells (PD-1+ICOS+CXCR5+CD45RO+CD4+CD3+). As expected, FACS-sorted Tfh cells, the primary source of IL-21, induced immunoglobulin production by purified naïve B cells. Furthermore, we found that P. vivax infection alters the B cell compartment and these alterations were dependent on the number of previous infections. First exposure leads to increased proportions of activated and atypical memory B cells and decreased frequencies of classical memory B cells, whereas patients that experienced multiple episodes displayed lower proportions of atypical B cells and higher frequencies of classical memory B cells. Despite the limited sample size, but consistent with the latter finding, the data suggest that patients who had more than five infections harbored more Tfh cells and produce more specific antibodies. P. vivax infection triggers IL-21 production by Tfh that impact B cell responses in humans. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Malária. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Centro de Pesquisas em Medicina Tropical de Rondônia. Porto Velho, RO, Brazil | pt_BR |
| Affilliation | Centro de Pesquisas em Medicina Tropical de Rondônia. Porto Velho, RO, Brazil | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Immunobiology Section Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, Maryland, United States of America | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Malaria | pt_BR |
| Subject | B cells | pt_BR |
| Subject | Plasmodium | pt_BR |
| Subject | Memory B cells | pt_BR |
| Subject | Antibodies | pt_BR |
| Subject | Plasma cells | pt_BR |
| Subject | T cells | pt_BR |
| Subject | Enzyme-linked immunoassays | pt_BR |
| Embargo date | 2022-01-01 | |
