| Author | Melo, Cristiane Moutinho Lagos de | |
| Author | Porto, Camila Souza | |
| Author | Melo-Júnior, Mário Ribeiro | |
| Author | Mendes, Chirleanny Maciel | |
| Author | Cavalcanti, Carmelita C Bezerra | |
| Author | Coelho, Luana Cassandra Breitenbach Barroso | |
| Author | Porto, Ana Lúcia Figueiredo | |
| Author | Leão, Ana Maria dos Anjos Carneiro | |
| Author | Correia, Maria Tereza dos Santos | |
| Access date | 2018-04-23T13:46:25Z | |
| Available date | 2018-04-23T13:46:25Z | |
| Document date | 2011 | |
| Citation | MELO, C. M. L. DE et al. Healing activity induced by Cramoll 1,4 lectin in healthy and immunocompromised mice. International Journal of Pharmaceutics, v. 408, n. 1–2, p. 113–119, abr. 2011. | pt_BR |
| ISSN | 1873-3476 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26028 | |
| Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Cratylia mollis | pt_BR |
| Subject in Portuguese | Lectina | pt_BR |
| Subject in Portuguese | Ferida | pt_BR |
| Subject in Portuguese | Imunocomprometido | pt_BR |
| Subject in Portuguese | Ratos | pt_BR |
| Title | Healing activity induced by Cramoll 1,4 lectin in healthy and immunocompromised mice | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.ijpharm.2011.02.011 | |
| Abstract | Cramoll 1,4 is a lectin extracted from seeds of Cratylia mollis Mart. Many assays have shown the cytokine release activity and pro-inflammatory profile of this lectin. Here, we used Cramoll 1,4 in the treatment of cutaneous wounds in normal and immunocompromised mice for available your cicatricial power. Surgical wounds were treated daily with a topical administration of Cramoll 1,4 and parameters as edema, hyperemia, scab, granulation and scar tissues as well as contraction of wounds were analyzed. Cramoll 1,4 wounds showed higher edema and arrival of more polimorphonuclear cells at the site of lesions. Granulation tissue and collagen fiber deposition were observed with higher intensity in all Cramoll 1,4 treated wounds and promoted excellent closing and repair of lesions in less time than other groups. Results showed that Cramoll 1,4 lectin was effective in the repair of experimental lesions in mice and can be used as a future cicatricial compound. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami – LIKA. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami – LIKA. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami – LIKA. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami – LIKA. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Departamento de Bioquímica. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami – LIKA. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Departamento de Morfologia e Fisiologia Animal - DMFA. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Recife, PE, Brasil. | pt_BR |
| Subject | Cratylia mollis | pt_BR |
| Subject | Lectin | pt_BR |
| Subject | Wound | pt_BR |
| Subject | Immunocompromised | pt_BR |
| Subject | Mice | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Modelos de Doença Animal | pt_BR |
| DeCS | Fabaceae / química | pt_BR |
| DeCS | Fêmea | pt_BR |
| DeCS | Hospedeiro imunocomprometido | pt_BR |
| DeCS | Ratos | pt_BR |
| DeCS | Infiltração de Neutrófilos / efeitos de drogas | pt_BR |
| DeCS | Infiltração de Neutrófilos / imunologia | pt_BR |
| DeCS | Neutrófilos / citologia | pt_BR |
| DeCS | Neutrófilos / efeitos de drogas | pt_BR |
| DeCS | Neutrófilos / imunologia | pt_BR |
| DeCS | Lectinas vegetais / isolamento e purificação | pt_BR |
| DeCS | Lectinas vegetais / uso terapêutico | pt_BR |
| DeCS | Sementes / química | pt_BR |
| DeCS | Pele / efeitos de drogas | pt_BR |
| DeCS | Pele / imunologia | pt_BR |
| DeCS | Pele / lesões | pt_BR |
| DeCS | Pele / patologia | pt_BR |
| DeCS | Cicatrização / efeitos de drogas | pt_BR |
| DeCS | Cicatrização / imunologia | pt_BR |
| DeCS | Feridas Penetrantes / quimioterapia | pt_BR |
| DeCS | Feridas Penetrantes / imunológicas | pt_BR |
| DeCS | Feridas Penetrantes / Patologia | pt_BR |
| Embargo date | 2050-01-01 | |
