| Author | Melo, Cristiane Moutinho Lagos de | |
| Author | Lima, Amanda Lucena Rosendo de | |
| Author | Beltrão, Eduardo Isidoro Carneiro | |
| Author | Cavalcanti, Carmelita C Bezerra | |
| Author | Melo-Júnior, Mário Ribeiro de | |
| Author | Montenegro, Silvia Maria L. | |
| Author | Coelho, Luana Cassandra B. Barroso | |
| Author | Correia, Maria Tereza dos Santos | |
| Author | Carneiro-Leão, Ana Maria dos Anjos | |
| Access date | 2018-04-23T14:06:39Z | |
| Available date | 2018-04-23T14:06:39Z | |
| Document date | 2011 | |
| Citation | MELO, C. M. L. DE et al. Potential effects of Cramoll 1,4 lectin on murine Schistosomiasis mansoni. Acta Tropica, v. 118, n. 2, p. 152–158, maio 2011. | pt_BR |
| ISSN | 1873-6254 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26030 | |
| Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | pt_BR |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Cratylia mollis | pt_BR |
| Subject in Portuguese | Lectina | pt_BR |
| Subject in Portuguese | Esquistossomose | pt_BR |
| Subject in Portuguese | Cramoll 1,4 | pt_BR |
| Subject in Portuguese | S . mansoni | pt_BR |
| Title | Potential effects of Cramoll 1,4 lectin on murine Schistosomiasis mansoni | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.actatropica.2011.01.008 | |
| Abstract | Cratylia mollis is a natural forage plant from the Northeast of Brazil. C. mollis seed lectin (Cramoll) containing molecular forms 1 and 4 (Cramoll 1,4) has shown anti-inflammatory and wound-healing activities. This work analyzed the effect of Cramoll 1,4 on experimental schistosomiasis in mice. Experimental groups (n=15/group) were composed of female albino Swiss mice, which were subcutaneously and caudally infected with Schistosoma mansoni (BH strain, 100 cercariae/mouse) and were treated with an intraperitoneal dose after infection as follows: (1) Cramoll 1,4 (50 mg kg(-1) single dose - after 40 days of infection), (2) Cramoll 1,4 (7 mg kg(-1) daily dose - for 7 days after infection) and control (untreated mice). Mice were sacrificed 8 weeks after infection and adult worms were recovered from the portal-hepatic system. Livers were fixed in 10% (v/v) formaldehyde/0.15M NaCl and tissue sections were processed for haematoxilin and Masson's trichrome stainings. Mice infected subcutaneously harboured no or very few worms and hence the effect of Cramoll 1,4 could not be assessed. Results (P≤0.05) were obtained with Cramoll 1,4 using the two treatments, with reduction of: egg excretion (79 and 80%), adult worm recovery (71 and 79%) and liver granulomas (40 and 73.5%) in relation to control. This study showed the potential anti-helminthic activity of Cramoll 1,4 when tested against Schistosomiasis mansoni infection in mice. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunogenética. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Bioquímica. Recife, PE, Brasil / Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami – LIKA. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Bioquímica. Recife, PE, Brasil / Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami – LIKA. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami – LIKA. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami – LIKA. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunogenética. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Bioquímica. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Bioquímica. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal Rural de Pernambuco. Departamento de Morfologia e Fisiologia Animal. Recife, PE, Brasil. | pt_BR |
| Subject | Cratylia mollis | pt_BR |
| Subject | Lectin | pt_BR |
| Subject | Schistosomiasis | pt_BR |
| Subject | Cramoll 1,4 | pt_BR |
| Subject | S . mansoni | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Anti-helmínticos / administração & dosagem | pt_BR |
| DeCS | Anti-helmínticos / isolamento e purificação | pt_BR |
| DeCS | Brasil | pt_BR |
| DeCS | Modelos de Doença Animal | pt_BR |
| DeCS | Fabaceae / química | pt_BR |
| DeCS | Fêmea | pt_BR |
| DeCS | Injeções intraperitoneais | pt_BR |
| DeCS | Lectinas / administração & dosagem | pt_BR |
| DeCS | Lectinas / isolamento e purificação | pt_BR |
| DeCS | Fígado / parasitologia | pt_BR |
| DeCS | Fígado / patologia | pt_BR |
| DeCS | Ratos | pt_BR |
| DeCS | Contagem de Ovos Parasitas | pt_BR |
| DeCS | Veia Porta / parasitologia | pt_BR |
| DeCS | Schistosoma mansoni / efeitos de drogas | pt_BR |
| DeCS | Esquistossomose mansoni / quimioterapia | pt_BR |
| DeCS | Sementes / química | pt_BR |
| DeCS | Resultado do tratamento | pt_BR |
| Embargo date | 2050-01-01 | |
