| Author | Coutinho, Eridan M. | |
| Author | Oliveira, Sheilla A. de | |
| Author | Barros, Andréia F. de | |
| Author | Silva, Fabiana L. | |
| Author | Ramos, Renata P. | |
| Access date | 2018-04-26T12:34:37Z | |
| Available date | 2018-04-26T12:34:37Z | |
| Document date | 2010 | |
| Citation | COUTINHO, E. M. et al. Manson’s schistosomiasis in the undernourished mouse: some recent findings. Memorias Do Instituto Oswaldo Cruz, v. 105, n. 4, p. 359–366, jul. 2010. | pt_BR |
| ISSN | 1678-8060 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26122 | |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Schistosoma mansoni | pt_BR |
| Subject in Portuguese | Desnutrição | pt_BR |
| Subject in Portuguese | Imunopatologia | pt_BR |
| Title | Manson's schistosomiasis in the undernourished mouse: some recent findings | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/S0074-02762010000400002 | |
| Abstract | This paper deals with current knowledge of the interrelationships between Schistosoma infection and malnutrition. It emphasizes the relevance of these investigations in the face of dynamic and evolving changes occurring in population diets and changes in the epidemiological patterns of schistosomiasis in endemic countries. The paper further discusses the basis for continuing the studies on this subject and the reasons why it represents a misunderstood association. This review also focuses on the cellular and humoral immune responses in the undernourished mouse model infected with Schistosoma mansoni, with updated information on the immune response in wild-type and iNOS knockout mice concerning soluble egg antigen specific antibodies and kinetics of IFN-gamma, IL-4, IL-10 and IL-13 cytokines, in the chronic phase of Manson's schistosomiasis. There is indication that schistosome-infected undernourished mice are able to develop a humoral immune response, but antibody titres are much lower than in the control animals. Cytokine production (IFN-gamma, IL-4, IL-10) is lower in the undernourished mice, but as infection progresses to the chronic phase its kinetics run an antagonistic course when compared to that of well-nourished animals. Marked variation in the secretion of IL-13 (a fibrogenic cytokine) could explain why undernourished mice do not develop liver "pipe-stem" fibrosis described in previous papers on well-nourished animals. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunopatologia e Biologia Molecular. Recife, PE, Brasil. | pt_BR |
| Subject | Schistosoma mansoni | pt_BR |
| Subject | Undernutrition | pt_BR |
| Subject | Immunopathology | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Anticorpos, Helmintos / imunologia | pt_BR |
| DeCS | Citocinas / imunologia | pt_BR |
| DeCS | Imunidade, Humoral / imunologia | pt_BR |
| DeCS | Cirrose Hepática Experimental / Imunologia | pt_BR |
| DeCS | Cirrose Hepática Experimental / parasitologia | pt_BR |
| DeCS | Cirrose Hepática Experimental / patologia | pt_BR |
| DeCS | Desnutrição / imunologia | pt_BR |
| DeCS | Desnutrição / patologia | pt_BR |
| DeCS | Ratos | pt_BR |
| DeCS | Ratos, Knockout | pt_BR |
| DeCS | Modelos Animal | pt_BR |
| DeCS | Schistosoma mansoni / imunologia | pt_BR |
| DeCS | Esquistossomose mansoni / imunologia | pt_BR |
| DeCS | Esquistossomose mansoni / patologia | pt_BR |
| xmlui.metadata.dc.subject.ods | 02 Fome zero e agricultura sustentável | |
