| Author | Costa, Maria F. S. | |
| Author | Bornstein, Victor U. | |
| Author | Candéa, André L. | |
| Author | Pons, Andréa Henriques | |
| Author | Henriques, Maria G. | |
| Author | Penido, Carmen | |
| Access date | 2018-04-26T15:50:28Z | |
| Available date | 2018-04-26T15:50:28Z | |
| Document date | 2012 | |
| Citation | COSTA, Maria F. S. et al. CCL25 induces α4β7 integrin-dependent migration of IL-17+ γδ T lymphocytes during an allergic reaction. Eur. J. Immunol., v.42, p.1250-1260, 2012. | pt_BR |
| ISSN | 0014-2980 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26141 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Quimiocinas | pt_BR |
| Subject in Portuguese | Alergia | pt_BR |
| Subject in Portuguese | Linfócitos T | pt_BR |
| Subject in Portuguese | Moléculas de adesão | pt_BR |
| Title | CCL25 induces α₄β₇ integrin-dependent migration of IL-17⁺ γδ T lymphocytes during an allergic reaction | pt_BR |
| Type | Article | |
| DOI | 10.1002/eji.201142021 | |
| Abstract | Herein, we provide evidence that during allergic inflammation, CCL25 induces the selective migration of IL-17(+) γδ T cells mediated by α(4) β(7) integrin. Intrapleural injection of CCL25 into ovalbumin (OVA)-immunized C57BL/6 mice triggered the accumulation of γδ T lymphocytes expressing CCR9 (CCL25 receptor) and α(4) β(7) integrin in the pleura, but failed to attract αβ T lymphocytes. CCL25 attracted CCR6(+) γδ T cells producing IL-17 (but not IFN-γ or IL-4). OVA challenge triggered increased production of CCL25 followed by the accumulation of CCR9(+) , α(4) β(7) (+) , and CCR6(+) /IL-17(+) γδ T cells into the pleural cavities of OVA-immunized mice, which was inhibited by the in vivo neutralization of CCL25. The in vivo blockade of α(4) β(7) integrin also inhibited the migration of IL-17(+) γδ T lymphocytes (but not of αβ T lymphocytes) into mouse pleura after OVA challenge, suggesting that the CCL25/α(4) β(7) integrin pathway is selective for γδ T cells. In addition, α(4) β(7) integrin blockade impaired the in vitro transmigration of γδ T cells across endothelium (which expresses α(4) β(7) ligands VCAM-1 and MadCAM-1), which was induced by CCL25 and by cell-free pleural washes recovered from OVA-challenged mice. Our results reveal that during an allergic reaction, CCL25 drives IL-17(+) γδ T-cell mobilization to inflamed tissue via α(4) β(7) integrin and modulates IL-17 levels. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Farmanguinhos. Laboratório de Farmacologia Aplicada. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Farmanguinhos. Laboratório de Farmacologia Aplicada. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Farmanguinhos. Laboratório de Farmacologia Aplicada. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Farmanguinhos. Laboratório de Farmacologia Aplicada. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Farmanguinhos. Laboratório de Farmacologia Aplicada. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Adhesion molecules | pt_BR |
| Subject | Allergy | pt_BR |
| Subject | CCL25 | pt_BR |
| Subject | Chemokines | pt_BR |
| Subject | T Cells | pt_BR |
| e-ISSN | 1521-4141 | |
| Embargo date | 2030-01-01 | |
