| Author | Castro, Carlos A. Velasco de | |
| Author | Grinsztejn, Beatriz | |
| Author | Veloso,Valdiléa G. | |
| Author | Bastos, Francisco Inácio Pinkusfeld Monteiro | |
| Author | Pilotto, Jose Henrique da Silva | |
| Author | Morgado, Mariza Gonçalves | |
| Access date | 2011-05-06T16:53:12Z | |
| Available date | 2011-05-06T16:53:12Z | |
| Document date | 2010 | |
| Citation | CASTRO,Carlos A. Velasco de et al. Prevalence, estimated HIV-1 incidence and viral diversity among people seeking voluntary counseling and testing services in Rio de Janeiro, Brazil. BMC Infectious Diseases, v. 10, p. 1-7, 2010. | en_US |
| ISSN | 1471-2334 | |
| URI | https://www.arca.fiocruz.br/handle/icict/2620 | |
| Language | eng | en_US |
| Publisher | BioMed Central | en_US |
| Rights | open access | |
| Subject in Portuguese | HIV-1 | en_US |
| Subject in Portuguese | Diversidade viral | en_US |
| Subject in Portuguese | Rio de Janeiro | en_US |
| Subject in Portuguese | Brasil | en_US |
| Subject in Portuguese | Teste de incidência | en_US |
| Title | Prevalence, estimated HIV-1 incidence and viral diversity among people seeking voluntary counseling and testing services in Rio de Janeiro, Brazil | en_US |
| Type | Article | |
| DOI | 10.1186/1471-2334-10-224 | |
| Abstract | Background: BED-EIA HIV-1 Incidence Test (BED-CEIA) has been described as a tool to discriminate recent (RS) from long-term (LTS) seroconversion of HIV-1 infection, contributing to a better understanding of the dynamics of the HIV/AIDS epidemic over time. This study determined the prevalence, estimated incidence and HIV-1 subtype infection among individuals seeking testing in Voluntary Counseling and Testing centers (VCTs) from Rio de Janeiro, Brazil. Methods: Demographics and behavioral data were obtained from 434 individuals, diagnosed as HIV-positive among 9,008 volunteers screened from November 2004 to October 2005 in three VCTs located in the Rio de Janeiro Metropolitan area, Brazil. BED-CEIA protocol was performed to identify RS. DNA samples from RS and a subset of LTS (under a proportion of 1:2) were selected for gp120 C2-V3 and pol (protease and reverse transcriptase) regions genomic sequencing. Results: Overall HIV-1 prevalence was 4.8%. Sixty-one of 434 seropositive individuals were classified as RS,
corresponding to an incidence rate of 1.68%/year (95%CI 1.26% -2.10%). Estimated incidence between Men Who Have Sex with Men (MSM) was 11 times higher than among heterosexual men and 55% of the new cases were identified in volunteers aged 25-40 years. A similar distribution of different HIV-1 subtypes was found among RS and LTS. Conclusions: Our data suggest that prevention for MSM remains a challenge and efforts focusing on prevention targeting this population should be prioritized. No significant changes in HIV-1 subtypes were observed among the RS and LTS subgroups. One case of HIV-1 AUK (pol)/A (env) recombinant genome was detected for the first time in Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Comunicação e Informação Científica e Tecnológica em Saúde. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | HIV-1 | en_US |
| Subject | Viral diversity | en_US |
| Subject | Rio de Janeiro | en_US |
| Subject | Brazil | en_US |
| Subject | Incidence test | en_US |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
