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AutorCurvo, Eduardo O. V.
AutorFerreira, Roberto R.
AutorMadeira, Fabiana S.
AutorAlves, Gabriel F.
AutorChambela, Mayara C.
AutorMendes, Veronica G.
AutorSangenis, Luiz Henrique C.
AutorWaghabi, Mariana C.
AutorSaraiva, Roberto M.
Fecha de acceso2018-05-03T13:48:47Z
Fecha de disponibilización2018-05-03T13:48:47Z
Fecha de publicación2018
ReferenciaCURVO, Eduardo O. V. et al. Correlation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 113, n. 4, p. 1-8, 2018.pt_BR
ISSN0074-0276pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/26235
Idiomaengpt_BR
EditorFundação Oswaldo Cruz. Instituto Oswaldo Cruzpt_BR
Derechos de autoropen access
Palabras clave en PortuguésDoença de Chagaspt_BR
Palabras clave en PortuguésEcocardiografiapt_BR
Palabras clave en PortuguésFator de necrose tumoralpt_BR
Palabras clave en PortuguésFator de crescimento transformador beta 1pt_BR
Palabras clave en PortuguésPeptídeo natriurético cerebralpt_BR
TítuloCorrelation of transforming growth factor-β1 and tumour necrosis factor levels with left ventricular function in Chagas diseasept_BR
Tipo del documentoArticle
DOI10.1590/0074-02760170440
Resumen en InglésBACKGROUND: Transforming growth factor β1 (TGF-β1) and tumour necrosis factor (TNF) have been implicated in Chagas disease pathophysiology and may correlate with left ventricular (LV) function. OBJECTIVES We determined whether TGF-β1 and TNF serum levels correlate with LV systolic and diastolic functions and brain natriuretic peptide (BNP) serum levels in chronic Chagas disease. METHODS: This cross-sectional study included 152 patients with Chagas disease (43% men; 57 ± 12 years old), classified as 53 patients with indeterminate form and 99 patients with cardiac form (stage A: 24, stage B: 25, stage C: 44, stage D: 6). TGF-β1, TNF, and BNP were determined by enzyme-linked immunosorbent assay ELISA. Echocardiogram was used to determine left atrial and LV diameters, as well as LV ejection fraction and diastolic function. FINDINGS: TGF-b1 serum levels were lower in stages B, C, and D, while TNF serum levels were higher in stages C and D of the cardiac form. TGF-β1 presented a weak correlation with LV diastolic function and LV ejection fraction. TNF presented a weak correlation with left atrial and LV diameters and LV ejection fraction. CONCLUSIONS: TNF is increased, while TGF-β1 is decreased in the cardiac form of chronic Chagas disease. TNF and TGF-β1 serum levels present a weak correlation with LV systolic and diastolic function in Chagas disease patients.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.pt_BR
Palavras clave en InglêsChagas Diseasept_BR
Palavras clave en InglêsTumour necrosis factorpt_BR
Palavras clave en InglêsTransforming growth factor beta 1pt_BR
Palavras clave en InglêsBrain natriuretic peptidept_BR
Palavras clave en InglêsEchocardiographypt_BR
e-ISSN1678-8060
xmlui.metadata.dc.subject.ods03 Saúde e Bem-Estar


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