| Author | Olivieri, B. P. | |
| Author | Vasconcellos, R. | |
| Author | Nóbrega, A. | |
| Author | Minoprio, P. | |
| Author | Kaveri, S. V. | |
| Author | Araujo-Jorge, Tania C. | |
| Access date | 2018-05-03T17:04:35Z | |
| Available date | 2018-05-03T17:04:35Z | |
| Document date | 2010 | |
| Citation | OLIVIERI, B. P. et al. Intravenous immunoglobulin increases survival time in the acute phase of experimental Chagas disease. Parasite Immunology, v.32,p.464–469, 2010. | pt_BR |
| ISSN | 0141-9838 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26250 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | fase aguda | pt_BR |
| Subject in Portuguese | imunoglobulina intravenosa | pt_BR |
| Subject in Portuguese | ratos | pt_BR |
| Title | Intravenous immunoglobulin increases survival time in the acute phase of experimental Chagas disease | pt_BR |
| Type | Article | |
| DOI | 10.1111/j.1365-3024.2010.01212.x | |
| Abstract | Chagas disease induced by Trypanosoma cruzi (Tc) infection is an important cause of mortality and morbidity affecting the cardiovascular system for which presently available therapies are insufficient and largely inadequate. Intravenous immunoglobulin (IVIg) is a therapeutic preparation containing normal polyspecific IgG obtained from plasma pools of several thousand healthy donors and is used in several autoimmune, inflammatory and infectious diseases. In the study of heart from mice chronically infected with Tc, we observed that IVIg restores type 1 atrioventricular block or bradycardia. In the present study, we investigated the effects of IVIg in acute Tc infection. Intravenous immunoglobulin administration after the first week of infection was associated with an increase in survival time. Taken together, results observed in the chronic and in the acute phase associate IVIg treatment with a favourable outcome in T. cruzi infection. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil / Fundação de Apoio à Escola Técnica.. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Departamento de Imunobiologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Institut Pasteur. Department of Immunology. Laboratoire d’Immunobiologie des Infections a Trypanosoma. Paris, France. | pt_BR |
| Affilliation | Université Pierre et Marie Curie. Centre de Recherche des Cordeliers, Equipe 16 - Immunopathology and Therapeutic Immunointervention. Paris, France / Université Paris Descartes. Paris, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | acute phase | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | mice | pt_BR |
| Subject | intravenous immunoglobulin | pt_BR |
| e-ISSN | 1365-3024 | |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
