| Author | Santos, R. L. | |
| Author | Farias, M. L. F. de | |
| Author | Mendonça, L. M. C. de | |
| Author | Gonçalves, R. T. | |
| Author | Martins, M. A. | |
| Author | Souza, M. M. G. de | |
| Access date | 2018-05-08T16:23:09Z | |
| Available date | 2018-05-08T16:23:09Z | |
| Document date | 2010 | |
| Citation | SANTOS, R. L. et al. Effects of immunosuppressant FK-506 on tooth movement. Orthodontics & Craniofacial Research, v.13, p. 153-161, 2010, | pt_BR |
| ISSN | 1601-6335 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26327 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | osso | pt_BR |
| Subject in Portuguese | imunossupressor | pt_BR |
| Subject in Portuguese | ortodontia | pt_BR |
| Subject in Portuguese | movimento dentário | pt_BR |
| Title | Effects of immunosuppressant FK-506 on tooth movement | pt_BR |
| Type | Article | |
| Abstract | Objective – To test the hypothesis that immunosuppressant tacrolimus treatment
can interfere with bone turnover and rate of tooth movement.
Material and Methods – One-hundred twenty Wistar male rats were divided into
four groups: Group 1 (rats subjected to orthodontic movement plus treatment with
saline solution vehicle), Group 2 (rats subjected to orthodontic movement plus
treatment with FK506), Group 3 (rats treated with FK506 only), and Group 4 (rats
treated with saline solution vehicle). The maxillary incisors were laterally moved with
a reciprocal load of 35 cN. The dosage of FK506 was 2 mg⁄ kg ⁄ day. Howship s
lacunae, osteoclasts, and macrophages were counted.
Results – Tooth movement was found to be greater in Group 1 than in Group 2 for all
time periods (on days 3, 7, and 14), although a significant difference was observed
only on days 7 and 14 (p < 0.05). The number of osteoclasts was smaller in Group 1
than in Group 2, whereas the number of Howship s lacunae was greater.
Conclusion – FK506 has the capacity of promoting osteoclasts inhibition with
probable osteoclastic apoptosis of alveolar bone following tooth movement. | pt_BR |
| Affilliation | Universidade de Alfenas. MG, Brasil / Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro,Departamento de Endocrinologia, Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro, Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Nefrologia. Unidade de Transplante Renal. Rio de Janeiro, R, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Departamento de Odontoperdiatria e Ortodontíca. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | bone | pt_BR |
| Subject | immunosuppressant | pt_BR |
| Subject | orthodontics | pt_BR |
| Subject | tooth movement | pt_BR |
| e-ISSN | 1601-6343 | |
| Embargo date | 2030-01-01 | |
